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手术在颈部淋巴结结核治疗中的作用

The Role of Surgery in the Treatment of Cervical Lymph Node Tuberculosis.

作者信息

Tahiri Ilias, Yacoubi Rim, Elhouari Othman, Anajar Said, Loubna Taali, Hajjij Amal, Zalagh Mohammed, Snoussi Khalid, Essaadi Mustapha, Benariba Fouad

机构信息

Otolaryngology - Head and Neck Surgery, Mohamed VI University of Health Sciences/Cheikh Khalifa International University Hospital, Casablanca, MAR.

Otolaryngology - Head and Neck Surgery, Mohammed V Military Training Hospital, Rabat, MAR.

出版信息

Cureus. 2023 May 10;15(5):e38824. doi: 10.7759/cureus.38824. eCollection 2023 May.

Abstract

Cervical lymph node tuberculosis is a public health problem in Morocco and the rest of the world. Its paucibacillary nature makes diagnosis and treatment difficult. This is a descriptive-analytical retrospective study presenting 104 cases of patients with manifestations of cervical lymph node tuberculosis confirmed by pathological examination (100%), associated in some cases with positive bacteriology (40.6%), treated and followed up in the otolaryngology (ENT) department of the Cheikh Khalifa International University Hospital (HUICK) over a period of 5 years and 9 months (from January 01, 2017, to September 30, 2022). In our study, 14 patients (i.e., 13.5%) had a history of tuberculosis (all locations); only four (i.e., 3.8%) of them had confirmed cervical lymph node tuberculosis, of which three were still under treatment: two of them presented for treatment failure (i.e., 1.9%) and one patient for a paradoxical reaction (i.e., 1%). Three pulmonary locations (i.e., 2.9%) and one mediastinal location (i.e., 1%) were found. Surgery associated with histological study was the key to the diagnosis of tuberculosis in our study. Its procedures were: excisional biopsy for 26 patients (i.e., 25%), adenectomy for 54 patients (i.e., 51.9%), lymph node dissection for 15 patients (i.e., 14.4%), and lymphadenectomy for nine patients (i.e., 8.7%). In some cases, drainage (+/- curettage) was recommended in addition to the surgical procedure in 14 patients (i.e., 13.5%). All our patients benefited from post-surgical anti-bacillary treatment. Lymphorrhea was the only operative complication and it affected two patients (i.e., 1.9%). Meanwhile, the relapse rate was 10.6% (i.e., 11 patients), the treatment failure rate was 3.8% (i.e., four patients), and the paradoxical reaction affected 2.9% (i.e., three patients). The latter had all benefited from a simple biopsy. This indicates that a more extensive surgical procedure gives better results with a better healing rate. In conclusion, anti-bacillary treatment remains the reference treatment for lymph node tuberculosis. However, surgery holds great promise as the first-line treatment in case of fistula or abscess or in the event of failure or if complications occur.

摘要

颈部淋巴结结核在摩洛哥及世界其他地区都是一个公共卫生问题。其菌量少的特性使得诊断和治疗都很困难。这是一项描述性分析回顾性研究,呈现了104例经病理检查确诊(100%)有颈部淋巴结结核表现的患者,部分病例伴有细菌学阳性结果(40.6%),在谢赫·哈利法国际大学医院(HUICK)耳鼻喉科接受了5年9个月(从2017年1月1日至2022年9月30日)的治疗和随访。在我们的研究中,14例患者(即13.5%)有结核病史(累及所有部位);其中仅有4例(即3.8%)确诊为颈部淋巴结结核,其中3例仍在接受治疗:2例因治疗失败前来就诊(即1.9%),1例因反常反应前来就诊(即1%)。发现3例肺部病变(即2.9%)和1例纵隔病变(即1%)。手术联合组织学检查是我们研究中结核病诊断的关键。其手术方式有:26例患者接受切除活检(即25%),54例患者接受腺切除术(即51.9%),15例患者接受淋巴结清扫术(即14.4%),9例患者接受淋巴结切除术(即8.7%)。在某些情况下,14例患者(即13.5%)除手术外还建议进行引流(±刮除术)。我们所有患者均接受了术后抗结核治疗。淋巴漏是唯一的手术并发症,影响了2例患者(即1.9%)。同时,复发率为10.6%(即11例患者),治疗失败率为3.8%(即4例患者),反常反应影响了2.9%(即3例患者)。后者均接受了简单活检。这表明更广泛的手术操作能带来更好的结果和更高的愈合率。总之,抗结核治疗仍然是淋巴结结核的标准治疗方法。然而,在出现瘘管或脓肿的情况下,或在治疗失败或发生并发症时,手术作为一线治疗方法具有很大前景。

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