Tahiri Ilias, Yacoubi Rim, Elhouari Othman, Anajar Said, Loubna Taali, Hajjij Amal, Zalagh Mohammed, Snoussi Khalid, Essaadi Mustapha, Benariba Fouad
Otolaryngology - Head and Neck Surgery, Mohamed VI University of Health Sciences/Cheikh Khalifa International University Hospital, Casablanca, MAR.
Otolaryngology - Head and Neck Surgery, Mohammed V Military Training Hospital, Rabat, MAR.
Cureus. 2023 May 10;15(5):e38824. doi: 10.7759/cureus.38824. eCollection 2023 May.
Cervical lymph node tuberculosis is a public health problem in Morocco and the rest of the world. Its paucibacillary nature makes diagnosis and treatment difficult. This is a descriptive-analytical retrospective study presenting 104 cases of patients with manifestations of cervical lymph node tuberculosis confirmed by pathological examination (100%), associated in some cases with positive bacteriology (40.6%), treated and followed up in the otolaryngology (ENT) department of the Cheikh Khalifa International University Hospital (HUICK) over a period of 5 years and 9 months (from January 01, 2017, to September 30, 2022). In our study, 14 patients (i.e., 13.5%) had a history of tuberculosis (all locations); only four (i.e., 3.8%) of them had confirmed cervical lymph node tuberculosis, of which three were still under treatment: two of them presented for treatment failure (i.e., 1.9%) and one patient for a paradoxical reaction (i.e., 1%). Three pulmonary locations (i.e., 2.9%) and one mediastinal location (i.e., 1%) were found. Surgery associated with histological study was the key to the diagnosis of tuberculosis in our study. Its procedures were: excisional biopsy for 26 patients (i.e., 25%), adenectomy for 54 patients (i.e., 51.9%), lymph node dissection for 15 patients (i.e., 14.4%), and lymphadenectomy for nine patients (i.e., 8.7%). In some cases, drainage (+/- curettage) was recommended in addition to the surgical procedure in 14 patients (i.e., 13.5%). All our patients benefited from post-surgical anti-bacillary treatment. Lymphorrhea was the only operative complication and it affected two patients (i.e., 1.9%). Meanwhile, the relapse rate was 10.6% (i.e., 11 patients), the treatment failure rate was 3.8% (i.e., four patients), and the paradoxical reaction affected 2.9% (i.e., three patients). The latter had all benefited from a simple biopsy. This indicates that a more extensive surgical procedure gives better results with a better healing rate. In conclusion, anti-bacillary treatment remains the reference treatment for lymph node tuberculosis. However, surgery holds great promise as the first-line treatment in case of fistula or abscess or in the event of failure or if complications occur.
颈部淋巴结结核在摩洛哥及世界其他地区都是一个公共卫生问题。其菌量少的特性使得诊断和治疗都很困难。这是一项描述性分析回顾性研究,呈现了104例经病理检查确诊(100%)有颈部淋巴结结核表现的患者,部分病例伴有细菌学阳性结果(40.6%),在谢赫·哈利法国际大学医院(HUICK)耳鼻喉科接受了5年9个月(从2017年1月1日至2022年9月30日)的治疗和随访。在我们的研究中,14例患者(即13.5%)有结核病史(累及所有部位);其中仅有4例(即3.8%)确诊为颈部淋巴结结核,其中3例仍在接受治疗:2例因治疗失败前来就诊(即1.9%),1例因反常反应前来就诊(即1%)。发现3例肺部病变(即2.9%)和1例纵隔病变(即1%)。手术联合组织学检查是我们研究中结核病诊断的关键。其手术方式有:26例患者接受切除活检(即25%),54例患者接受腺切除术(即51.9%),15例患者接受淋巴结清扫术(即14.4%),9例患者接受淋巴结切除术(即8.7%)。在某些情况下,14例患者(即13.5%)除手术外还建议进行引流(±刮除术)。我们所有患者均接受了术后抗结核治疗。淋巴漏是唯一的手术并发症,影响了2例患者(即1.9%)。同时,复发率为10.6%(即11例患者),治疗失败率为3.8%(即4例患者),反常反应影响了2.9%(即3例患者)。后者均接受了简单活检。这表明更广泛的手术操作能带来更好的结果和更高的愈合率。总之,抗结核治疗仍然是淋巴结结核的标准治疗方法。然而,在出现瘘管或脓肿的情况下,或在治疗失败或发生并发症时,手术作为一线治疗方法具有很大前景。