CIRI - Centre International de Recherche en Infectiologie, Team GIMAP (Saint-Etienne), Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, UJM, Lyon, France.
Boehringer Ingelheim, Global Innovation, Saint-Priest, France.
Clin Microbiol Rev. 2023 Sep 21;36(3):e0016422. doi: 10.1128/cmr.00164-22. Epub 2023 Jun 12.
and belong to the genus , which comprises 14 other species. is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At the same time, it is increasingly implicated in human infections, while remaining an important pathogen in the veterinary field. Both can evade and modulate host immune responses to support their persistence, although it is more pronounced in infection. The protective immune responses elicited by both pathogens are comparable, while there are important characteristics in the mechanisms that differ. However, pathogenesis is more difficult to decipher in animal models than those of because of its restriction to humans. Nevertheless, the licensed vaccines for each are different in terms of formulation, route of administration and immune responses induced, with no known cross-reaction between them. Moreover, the target of the mucosal tissues and the induction of long-lasting cellular and humoral responses are required to control and eliminate . In addition, the interaction between both veterinary and human fields are essential for the control of this genus, by preventing the infections in animals and the subsequent zoonotic transmission to humans.
和属于,其中包含 14 个其他物种。是引起人类百日咳的病原体,在儿童中是一种严重的感染,在成人中则较为轻微或慢性。这些感染仅限于人类,目前在全球范围内呈上升趋势。参与多种哺乳动物的呼吸道感染。例如,犬传染性呼吸道疾病综合征(CIRDC),其特征是狗的慢性咳嗽。同时,它越来越多地与人类感染有关,同时仍然是兽医领域的重要病原体。和都可以逃避和调节宿主的免疫反应,以支持它们的持续存在,尽管在感染中更为明显。两种病原体引起的保护性免疫反应相当,但在机制上存在重要的差异。然而,由于其在人类中的限制,的发病机制比的发病机制更难在动物模型中进行破译。尽管如此,由于配方、给药途径和诱导的免疫反应不同,每种的许可疫苗都有所不同,并且它们之间没有已知的交叉反应。此外,需要针对黏膜组织和诱导持久的细胞和体液反应来控制和消除。此外,兽医和人类领域之间的相互作用对于控制该属至关重要,通过防止动物感染和随后的人畜共患传播到人类。