State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, 818 Meiling Avenue, Nanchang, Jiangxi 330004, People's Republic of China.
J Nat Prod. 2023 Jun 23;86(6):1606-1614. doi: 10.1021/acs.jnatprod.3c00300. Epub 2023 Jun 12.
Chemical investigation of the twigs of (Phyllanthaceae) led to the isolation of 10 undescribed lignans, sumatranins A-J (-). Compounds - are unprecedented furopyran lignans characterized by a unique 2,3,3a,9a-tetrahydro-4-furo[2,3-]chromene heterotricyclic framework. Compounds and are rare 9'--dibenzylbutane lignans. Structures were established based on analyses of spectroscopic data, X-ray crystallographic data, and experimental ECD spectra. Immunosuppressive assays revealed compounds and displayed moderate inhibitory effects with good selectivity indexes against LPS-induced B lymphocyte proliferation.
对 （藤黄科）小枝的化学研究导致分离出 10 个未描述的木脂素，苏门答腊素 A-J (-)。化合物 - 是前所未有的呋喃吡喃木脂素，其特征在于独特的 2,3,3a,9a-四氢-4-呋喃[2,3-]色烯杂三环骨架。化合物 和 是罕见的 9'--二苄基丁烷木脂素。结构是基于光谱数据分析、X 射线晶体学数据和实验 ECD 光谱确定的。免疫抑制试验表明，化合物 和 对 LPS 诱导的 B 淋巴细胞增殖具有中等抑制作用，且具有良好的选择性指数。
