早孕期超声诊断胎儿腭裂的性能：Meta 分析和系统评价。

The performance of first-trimester ultrasound in diagnosing fetal cleft palate: Meta-analysis and systematic review.

机构信息

Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, China.

Department of Obstetrics and Gynecology Ultrasound, Qingdao Women and Chlidren's Hospital, Qingdao, China.

出版信息

J Clin Ultrasound. 2023 Jul-Aug;51(6):1015-1023. doi: 10.1002/jcu.23507. Epub 2023 Jun 12.

DOI:10.1002/jcu.23507

PMID:37307333

Abstract

OBJECTIVE

This system review and meta-analysis was aim to evaluate the accuracy of prenatal ultrasound in diagnosing cleft palates (CPs) during first trimester.

DATA SOURCE

We systematically searched the databases of PubMed, Embase, and Cochrane Library for the articles, which assessed the accuracy of CPs diagnosed by ultrasound during first trimester.

REVIEW METHOD

The characteristics of the included studies were recorded. The quality of included studies was assessed by QUADAS-2. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the curve (AUC) were calculated using Meta-Disc software version 1.4. The publication bias was assessed by Stata software version 12.0.

RESULTS

This meta-analysis included 13 studies with 39 806 fetuses. The pooled sensitivity, specificity, PLR, NLR were 0.874, 0.999, 689.84, and 0.161, respectively. The DOR and AUC were 6651.3 and 0.9084, respectively.

CONCLUSION

The overall detection rate was 0.874, which indicated high value of first trimester ultrasound in diagnosing CPs.

摘要

目的

本系统评价和荟萃分析旨在评估产前超声在诊断早孕期腭裂（CPs）中的准确性。

资料来源

我们系统地检索了 PubMed、Embase 和 Cochrane Library 数据库中的文章，这些文章评估了早孕期超声诊断 CPs 的准确性。

复习方法

记录纳入研究的特征。使用 Meta-Disc 软件版本 1.4 评估纳入研究的质量。使用 QUADAS-2。使用 Meta-Disc 软件版本 1.4 计算汇总敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）和曲线下面积（AUC）。使用 Stata 软件版本 12.0 评估发表偏倚。