The Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, WuXi, Jiangsu 214151, China.
Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Mental Health Center, Guangdong Province, China.
Asian J Psychiatr. 2023 Aug;86:103639. doi: 10.1016/j.ajp.2023.103639. Epub 2023 May 22.
Gender differences have been found in several areas of individuals at clinical-high risk for psychosis(CHR). Therefore the risk of transition to psychosis may differ between male and female CHR, but previous work has not systematically reviewed and analyzed gender differences in conversion rates.We performed a meta-analysis according to PRISMA guidelines including all studies that assessed CHR with reliable instruments and provided data on the transition from male CHR and female CHR to psychosis to understand the conversion rate conversion in male and female CHR. Seventy-nine article were identified.A total of 1250 out of 5770 in the male CHR individuals, and 832 out of 4468 in the female CHR individuals translated to psychotic disorders. Transition prevalence were 19.4%(95%CI:14.2-25.8%)at 1 year, 20.6% at 2 year (95%CI:17.1-24.8%),24.3% at 3 years (95%CI:21.5-27.4%),26.3% at 4 years or older (95%CI:20.9-32.5%) and 22.3% at all (95%CI:20.0-24.8%) in male CHR and 17.7% (95%CI:12.6-24.4%) at 1 years, 17.5% (95%CI:14.2-21.4%) at 2 year, 19.9%(95%CI:17.3-0.228%) at 3 years,and 0.267 (95%CI:22.1-31.9%) at 4 years or older follow-up,20.4% at all (95%CI:18.1-22.9%) in female CHR. There were differences between the two groups in the overall conversion, the 2-year, and the 3-year follow up transition prevalence, which were higher in men CHR than in female CHR. Future research characterizing male versus female CHR is needed with the expectation that interventions will be developed that are tailored to the respective gender, further reducing the rate of conversion to CHR.
性别差异在处于精神病高危状态的个体的多个领域都有发现（CHR）。因此，男性和女性 CHR 向精神病的过渡风险可能不同，但以前的工作并未系统地审查和分析转化率的性别差异。我们根据 PRISMA 指南进行了荟萃分析，纳入了所有使用可靠工具评估 CHR 并提供了从男性 CHR 和女性 CHR 向精神病过渡数据的研究，以了解男性和女性 CHR 的转化率。确定了 79 篇文章。在男性 CHR 个体中，共有 1250 人（95%CI：14.2-25.8%）转化为精神病障碍，女性 CHR 个体中，共有 832 人（95%CI：14.2-25.8%）转化为精神病障碍。1 年内的转换发生率为 19.4%（95%CI：14.2-25.8%），2 年内为 20.6%（95%CI：17.1-24.8%），3 年内为 24.3%（95%CI：21.5-27.4%），4 年内或以上为 26.3%（95%CI：20.9-32.5%），所有随访期为 22.3%（95%CI：20.0-24.8%），在男性 CHR 中，1 年内为 17.7%（95%CI：12.6-24.4%），2 年内为 17.5%（95%CI：14.2-21.4%），3 年内为 19.9%（95%CI：17.3-0.228%），4 年内或以上为 0.267%（95%CI：22.1-31.9%），所有随访期为 20.4%（95%CI：18.1-22.9%）。在整体转化率、2 年和 3 年随访转化率方面，两组之间存在差异，男性 CHR 高于女性 CHR。需要对男性与女性 CHR 进行特征描述的进一步研究，期望开发出针对各自性别的干预措施，进一步降低向 CHR 转化的发生率。
