线粒体衍生的促动力蛋白2：一种潜在的抗肺纤维化因子。

MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria.

作者信息

Zhang Zewei, Chen Dongmei, Du Kaili, Huang Yaping, Li Xingzhe, Li Quwen, Lv Xiaoting

机构信息

School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, Fujian 350004, China.

Department of Laboratory Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China.

出版信息

Mitochondrion. 2023 Jul;71:76-82. doi: 10.1016/j.mito.2023.06.002. Epub 2023 Jun 10.

DOI:10.1016/j.mito.2023.06.002

PMID:37307934

Abstract

Pulmonary fibrosis (PF) is a serious lung disease characterized by diffuse alveolitis and disruption of alveolar structure, with a poor prognosis and unclear etiopathogenesis. While ageing, oxidative stress, metabolic disorders, and mitochondrial dysfunction have been proposed as potential contributors to the development of PF, effective treatments for this condition remain elusive. However, Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), a peptide encoded by the mitochondrial genome, has shown promising effects on glucose and lipid metabolism, cellular and mitochondrial homeostasis, as well as the reduction of systemic inflammatory responses, and is being investigated as a potential exercise mimetic. Additionally, dynamic expression changes of MOTS-c have been closely linked to ageing and ageing-related diseases, indicating its potential as an exercise mimetic. Therefore, the review aims to comprehensively analyze the available literature on the potential role of MOTS-c in improving PF development and to identify specific therapeutic targets for future treatment strategies.

摘要

肺纤维化（PF）是一种严重的肺部疾病，其特征为弥漫性肺泡炎和肺泡结构破坏，预后较差，病因发病机制尚不明确。虽然衰老、氧化应激、代谢紊乱和线粒体功能障碍被认为是PF发生发展的潜在因素，但针对这种疾病的有效治疗方法仍然难以捉摸。然而，线粒体12S rRNA-c开放阅读框（MOTS-c）是一种由线粒体基因组编码的肽，已显示出对葡萄糖和脂质代谢、细胞和线粒体稳态以及全身炎症反应的减轻具有有前景的作用，并且正在作为一种潜在的运动模拟物进行研究。此外，MOTS-c的动态表达变化与衰老及衰老相关疾病密切相关，表明其作为运动模拟物的潜力。因此，本综述旨在全面分析现有文献中关于MOTS-c在改善PF发展中的潜在作用，并确定未来治疗策略的特定治疗靶点。