Department of Periodontology, School of Stomatology, China Medical University, Nanjing North Street 117, Shenyang, China.
Clinical Medicine, Shenyang Medical College, Huanghe North Street 146, Shenyang, China.
Br J Oral Maxillofac Surg. 2023 Jul;61(6):394-402. doi: 10.1016/j.bjoms.2023.05.004. Epub 2023 May 16.
To investigate the relation between periodontal disease (PD) and oral squamous cell carcinoma (OSCC) we systematically searched records published up to August 2022. Odds ratios (OR) and relative risk (RR) with 95% confidence intervals (95% CI) were estimated to evaluate this relation, then sensitivity analysis was performed accordingly. Begg's test and Egger's test were used to detect publication bias. Out of 970 papers from several databases, 13 studies were included. Summary estimates showed that PD was positively associated with the prevalence of OSCC (OR = 3.28, 95% CI: 1.87 to 5.74), especially for severe PD (OR = 4.23, 95% CI: 2.92 to 6.13). No evident publication bias was revealed. No increased OSCC risk among patients with PD was shown according to the combined results (RR = 1.50, 95% CI: 0.93 to 2.42). Patients with OSCC exhibited significant differences in alveolar bone loss, clinical attachment loss, and bleeding on probing, when compared with controls. The systematic review and meta-analysis suggested that there was a positive association between PD and prevalence of OSCC. However, according to the current evidence, a causal relation is unclear.
为了研究牙周病（PD）和口腔鳞状细胞癌（OSCC）之间的关系，我们系统地检索了截至 2022 年 8 月发表的记录。使用优势比（OR）和相对风险（RR）及其 95%置信区间（95%CI）来评估这种关系，然后进行相应的敏感性分析。采用 Begg 检验和 Egger 检验来检测发表偏倚。从几个数据库中的 970 篇论文中，纳入了 13 项研究。汇总估计表明，PD 与 OSCC 的患病率呈正相关（OR=3.28，95%CI：1.87 至 5.74），尤其是重度 PD（OR=4.23，95%CI：2.92 至 6.13）。未发现明显的发表偏倚。根据综合结果，PD 患者的 OSCC 风险没有增加（RR=1.50，95%CI：0.93 至 2.42）。与对照组相比，患有 OSCC 的患者在牙槽骨丧失、临床附着丧失和探诊出血方面存在显著差异。系统评价和荟萃分析表明，PD 与 OSCC 的患病率之间存在正相关。然而，根据目前的证据，因果关系尚不清楚。
