Zanardo V, Marchesini L, Kirschner G
Department of Pediatrics, University of Padua, Italy.
Childs Nerv Syst. 1993 Dec;9(8):467-9. doi: 10.1007/BF00393551.
Blood levels of the monosialoganglioside GM1 (nomenclature according to Svennerholm) were tested at birth in the umbilical cord of 37 neonates and their mothers. Comparisons were made based on gestational age and modality of delivery. GM1 blood levels at birth were significantly higher in mothers than in newborns (373.66 +/- 56.83 ng/ml vs 217.95 +/- 21.24 ng/ml; P < 0.01). Newborns delivered by cesarean section showed levels of GM1 significantly higher than those delivered vaginally (298.97 +/- 38.55 ng/ml vs 169.62 +/- 12.62 ng/ml; P < 0.01), and preterm newborns had significantly higher levels of GM1 than full-term newborns (253.50 +/- 40.83 ng/ml vs 193.71 +/- 21.74 ng/ml; P < 0.01). No differences in blood levels of GM1 were observed in the mothers in relation to length of pregnancy or modality of delivery. The higher levels of GM1 observed in preterm newborns indicate an increased turnover and/or enhanced bioavailability of the monosialoganglioside GM1 for the developing central nervous system. Further data are required to evaluate the significance of the increased cord levels of GM1 in neonates after cesarean section.
在37名新生儿及其母亲的脐带中检测了单唾液酸神经节苷脂GM1（根据斯文内霍尔姆命名法）的血药浓度。根据胎龄和分娩方式进行了比较。母亲出生时的GM1血药浓度显著高于新生儿（373.66±56.83 ng/ml对217.95±21.24 ng/ml；P<0.01）。剖宫产出生的新生儿GM1水平显著高于阴道分娩的新生儿（298.97±38.55 ng/ml对169.62±12.62 ng/ml；P<0.01），早产儿的GM1水平显著高于足月儿（253.50±40.83 ng/ml对193.71±21.74 ng/ml；P<0.01）。未观察到母亲的GM1血药浓度在妊娠时长或分娩方式方面存在差异。早产儿中观察到的较高GM1水平表明，单唾液酸神经节苷脂GM1在发育中的中枢神经系统中的周转率增加和/或生物利用度提高。需要更多数据来评估剖宫产术后新生儿脐带血中GM1水平升高的意义。
