Kinnman E, Aldskogius H
Brain Res. 1986 Jul 2;377(1):73-82. doi: 10.1016/0006-8993(86)91192-3.
The anterograde transport of wheat germ agglutinin-horseradish peroxidase conjugate was used to study the normal distribution of sensory nerve axons in the plantar skin of the rat hindlimb and at various times after chronic sciatic nerve injury in adult and neonatal rats. In adults, thin saphenous nerve axons were found in a small area laterally to the normal saphenous nerve territory 2-24 weeks after sciatic nerve lesion. In neonatal rats, at 6 and 10 weeks after sciatic nerve injury thin saphenous nerve axons were found almost or all over the sole of the foot, respectively, and in all 5 toes. At longer survival times, the area innervated by saphenous nerve axons became smaller. However, this area was now occupied by thin, as well as coarse axons. When adult animals were subjected to saphenous nerve crush simultaneously with the sciatic nerve lesion, thin, as well as coarse, nerve axons were found laterally to the normal saphenous nerve territory. The findings indicate that thin cutaneous sensory axons of adult mammals can extend collateral sprouts in glabrous skin for a short distance. This capacity appears to be greater in neonatally lesioned animals, where it is present for coarse cutaneous sensory axons as well. However, after neonatal nerve injury collateral sprouts seem to disappear from the initially most distally reinnervated area. Regenerating sensory axons in adult rats seem to have a greater capacity for collateral sprouting than intact axons. Coarse and thin cutaneous sensory axons could be found in this instance. In all instances a great part of the plantar skin remained denervated, suggesting that there is an upper limit for the territory which can be maintained by cutaneous sensory neurons reinnervating glabrous skin.
运用小麦胚凝集素 - 辣根过氧化物酶共轭物的顺行运输，来研究大鼠后肢足底皮肤中感觉神经轴突的正常分布，以及成年和新生大鼠坐骨神经慢性损伤后不同时间点的情况。在成年大鼠中，坐骨神经损伤后2 - 24周，在隐神经正常分布区域外侧的一小片区域发现了细的隐神经轴突。在新生大鼠中，坐骨神经损伤后6周和10周，分别在几乎整个足底或全部5个脚趾发现了细的隐神经轴突。存活时间更长时，隐神经轴突支配的区域变小。然而，此时该区域被细轴突和粗轴突占据。当成年动物在坐骨神经损伤的同时接受隐神经挤压时，在隐神经正常分布区域外侧发现了细轴突和粗轴突。这些发现表明，成年哺乳动物的细皮肤感觉轴突可以在无毛皮肤中短距离延伸侧支芽。这种能力在新生期受损的动物中似乎更强，在这些动物中粗皮肤感觉轴突也有这种能力。然而，新生期神经损伤后，侧支芽似乎从最初最远端重新支配的区域消失。成年大鼠再生的感觉轴突似乎比完整轴突具有更强的侧支发芽能力。在这种情况下可以发现粗的和细的皮肤感觉轴突。在所有情况下，大部分足底皮肤仍无神经支配，这表明由重新支配无毛皮肤的皮肤感觉神经元维持的区域存在上限。
