Romandini S, Pich E M, Esposito E, Kruszewska A, Samanin R
Brain Res. 1986 Jul 9;377(2):351-4. doi: 10.1016/0006-8993(86)90880-2.
The effect of different manipulations of the nucleus medianus raphe (MR) on morphine analgesia was investigated in rats using the tail-immersion test. Electrolytic lesions of this structure antagonized morphine analgesia, while injections of 5,7-dihydroxytryptamine (to destroy serotonergic neurons) or ibotenic acid (to destroy cell bodies) in the medianus raphe did not alter the effect of morphine. Injection of naloxone (0.5 and 0.1 micrograms) in the MR antagonized morphine analgesia. These results suggest the importance of this structure for morphine analgesia in this test, although the substrates within the nucleus that mediate this action are still unknown.
采用尾浸法在大鼠中研究了中缝正中核（MR）的不同处理对吗啡镇痛的影响。该结构的电解损伤会拮抗吗啡镇痛作用，而在中缝正中核注射5,7-二羟色胺（以破坏血清素能神经元）或鹅膏蕈氨酸（以破坏细胞体）不会改变吗啡的作用。在中缝正中核注射纳洛酮（0.5和0.1微克）会拮抗吗啡镇痛作用。这些结果表明，在该试验中该结构对吗啡镇痛很重要，尽管介导这种作用的核内底物仍然未知。
