黄酮类化合物作用于癌细胞自噬和转移途径的不同分子。

Flavonoids target different molecules of autophagic and metastatic pathways in cancer cells.

作者信息

Hosseinzadeh Aysooda, Poursoleiman Faezeh, Biregani Akram Naghdipour, Esmailzadeh Ahmad

机构信息

Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Department of Cellular and Molecular Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Cancer Cell Int. 2023 Jun 12;23(1):114. doi: 10.1186/s12935-023-02960-4.

DOI:10.1186/s12935-023-02960-4

PMID:37308913

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10262367/

Abstract

Despite the success of cancer therapy, it has encountered a major obstacle due to the complicated nature of cancer, namely resistance. The recurrence and metastasis of cancer occur when anti-cancer therapeutic agents fail to eradicate all cancer cells. Cancer therapy aims to find the best agent that targets all cancer cells, including those sensitive or resistant to treatment. Flavonoids, natural products from our diet, show anti-cancer effects in different studies. They can inhibit metastasis and the recurrence of cancers. This review discusses metastasis, autophagy, anoikis in cancer cells, and their dynamic relationship. We present evidence that flavonoids can block metastasis and induce cell death in cancer cells. Our research suggests that flavonoids can serve as potential therapeutic agents in cancer therapy.

摘要

尽管癌症治疗取得了成功，但由于癌症的复杂性质，即耐药性，它遇到了一个主要障碍。当抗癌治疗药物未能根除所有癌细胞时，癌症就会复发和转移。癌症治疗旨在找到针对所有癌细胞的最佳药物，包括那些对治疗敏感或耐药的癌细胞。黄酮类化合物是我们饮食中的天然产物，在不同的研究中显示出抗癌作用。它们可以抑制癌症的转移和复发。这篇综述讨论了癌细胞中的转移、自噬、失巢凋亡及其动态关系。我们提供的证据表明，黄酮类化合物可以阻断癌细胞的转移并诱导其死亡。我们的研究表明，黄酮类化合物可以作为癌症治疗中的潜在治疗药物。