State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China.
Anal Chem. 2023 Jun 27;95(25):9453-9461. doi: 10.1021/acs.analchem.3c00074. Epub 2023 Jun 13.
Nanotheranostic platforms integrated with diagnostic and therapeutic functions have been widely developed for tumor medicine. However, the "always-on" nanotheranostic platforms suffer from poor tumor specificity, which may largely restrict therapeutic efficacy and prevent precise theranostics. Here, we develop an transformable pro-nanotheranostic platform (ZnS/CuO@ZIF-8@PVP) by encapsulating ZnS and CuO nanoparticles in a metal-organic framework (MOF) nanomaterial of ZIF-8 that allows activable photoacoustic (PA) imaging and synergistic photothermal/chemodynamic therapy (PTT/CDT) of tumors . It is shown that the pro-nanotheranostic platform gradually decomposes and releases ZnS nanoparticles and Cu ions in acidic conditions, which spontaneously trigger a cation exchange reaction and synthesize CuS nanodots with activated PA signals and PTT effects. Moreover, the excessive Cu ions function as Fenton-like catalysts and catalyze the production of highly reactive hydroxyl radicals (OH) for CDT using elevated levels of HO in tumor microenvironments (TMEs). studies demonstrate that the transformable pro-nanotheranostic platform can specifically image tumors via PA and photothermal imaging and efficiently ablate tumors through synergistic CDT/PTT. Our transformable pro-nanotheranostic platform could provide a new arsenal for precise theranostics in cancer therapy.
Nanotheranostic 平台集成了诊断和治疗功能，已广泛应用于肿瘤医学。然而，“常开”的纳米治疗平台存在较差的肿瘤特异性，这可能在很大程度上限制了治疗效果并阻碍了精确治疗。在这里，我们通过将 ZnS 和 CuO 纳米颗粒封装在允许激活光声（PA）成像和协同光热/化学动力学治疗（PTT/CDT）的金属有机框架（MOF）纳米材料 ZIF-8 中，开发了一种可转换的前纳米治疗平台（ZnS/CuO@ZIF-8@PVP）。结果表明，在前纳米治疗平台在酸性条件下逐渐分解并释放出 ZnS 纳米颗粒和 Cu 离子，这会自发引发阳离子交换反应并合成具有激活 PA 信号和 PTT 效应的 CuS 纳米点。此外，过量的 Cu 离子可作为类 Fenton 催化剂，利用肿瘤微环境（TME）中升高的 HO 水平，催化产生高反应性羟基自由基（OH）用于 CDT。研究表明，可转换的前纳米治疗平台可通过 PA 和光热成像特异性地对肿瘤进行成像，并通过协同 CDT/PTT 有效地消融肿瘤。我们的可转换的前纳米治疗平台为癌症治疗中的精确治疗提供了新的武器。
