State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, P. R. China.
J Mater Chem B. 2022 Jun 8;10(22):4274-4284. doi: 10.1039/d1tb02807c.
Specific tumor-responsive capabilities and efficient synergistic therapeutic performance are the keys to effective tumor treatment. Herein, AuNRs@SiO-RB@MnO was developed as a new type of tumor-responsive nanotheranostic for multimodal imaging and synergistic chemodynamic/photothermal therapy. In AuNRs@SiO-RB@MnO, the SiO layer wraps the AuNRs, providing light absorption in the second near-infrared (NIR-II) region. The SiO layer also adsorbs the MnO nanosheets, which have Fenton-like activity, resulting in a fluorescent sensing platform based on the fluorescence quenching properties of MnO for rhodamine B dye. The fluorescence can be recovered by the consumption of MnO by glutathione, which simultaneously produces Mn in the tumor region. The recovery of fluorescence reflects the consumption of glutathione and the increase in Mn, which produces hydroxyl radicals Fenton-like reaction in the tumor microenvironment to realize chemodynamic therapy. Meanwhile, the AuNRs are a good photothermal reagent that can effectively absorb NIR-II light and convert it into heat energy to kill tumor cells photothermal therapy. The NIR-II absorption performance of the AuNRs provides good photoacoustic imaging and deep photothermal performance, which is favorable for efficient NIR-II photoacoustic imaging-guided photothermal therapy. As a result, the AuNRs@SiO-RB@MnO nanotheranostic exhibits outstanding imaging and synergistic chemodynamic/photothermal therapeutic performance for tumor imaging and treatment.
特定的肿瘤响应能力和高效的协同治疗性能是有效肿瘤治疗的关键。在此，开发了 AuNRs@SiO-RB@MnO 作为一种新型的肿瘤响应型多功能诊疗纳米平台，用于协同化学动力学/光热治疗。在 AuNRs@SiO-RB@MnO 中，SiO 层包裹着 AuNRs，提供了在近红外二区（NIR-II）的光吸收。SiO 层还吸附了具有类 Fenton 活性的 MnO 纳米片，形成了基于 MnO 对罗丹明 B 染料荧光猝灭特性的荧光传感平台。MnO 可以被谷胱甘肽消耗，从而恢复荧光，同时在肿瘤区域产生 Mn。荧光的恢复反映了谷胱甘肽的消耗和 Mn 的增加，这在肿瘤微环境中产生了羟基自由基的类 Fenton 反应，实现了化学动力学治疗。同时，AuNRs 是一种良好的光热试剂，可有效吸收 NIR-II 光并将其转化为热能来杀死肿瘤细胞，实现光热治疗。AuNRs 的 NIR-II 吸收性能提供了良好的光声成像和深光热性能，有利于高效的 NIR-II 光声成像引导的光热治疗。因此，AuNRs@SiO-RB@MnO 纳米诊疗剂表现出了出色的肿瘤成像和协同化学动力学/光热治疗性能。
