Franssila K O, Harach H R
Cancer. 1986 Aug 1;58(3):715-9. doi: 10.1002/1097-0142(19860801)58:3<715::aid-cncr2820580319>3.0.co;2-p.
The thyroids from 93 autopsies performed on children and young adults younger than age 40 years, were subserially sectioned at 2- to 3-mm intervals. Thirteen thyroids revealed 17 foci of occult papillary carcinoma (OPC), giving a prevalence rate of 14%. The youngest affected patient was a boy aged 18 years. The prevalence rate of individuals between age 18 and 40 years was 27%. The rate appears to be rather constant in adults, although there may be a slight rise in middle age. The prevalence rate was higher for males, but no statistically significant difference was seen. The arise of OPCs after puberty would favor the view that hormonal factors are related to their appearance.
对93例年龄小于40岁的儿童和年轻人进行尸检，取出甲状腺，每隔2至3毫米进行连续切片。13例甲状腺发现17个隐匿性乳头状癌病灶，患病率为14%。最年轻的患病患者是一名18岁男孩。18至40岁个体的患病率为27%。尽管中年可能略有上升，但该患病率在成年人中似乎相当稳定。男性的患病率较高，但未见统计学上的显著差异。青春期后隐匿性乳头状癌的出现支持激素因素与其出现有关的观点。
