Lynch H T, Lynch J F
Cancer Genet Cytogenet. 1986 Aug;22(4):369-71. doi: 10.1016/0165-4608(86)90032-4.
We have provided intensive medical-genetic follow-up on a previously published cohort of 225 consecutively ascertained patients with verified breast cancer evaluated in our oncology clinic. Similar evaluation was performed on 103 newly ascertained breast cancer patients, giving a total of 328 consecutive patients with verified breast cancer. We believe that this represents one of the most intensive efforts of its type for meticulous documentation of genealogy and cancer of all anatomic sites on a series of breast cancer patients. The results showed that the familial and putative hereditary categories almost doubled among our original 225 breast cancer probands. We conclude that the impact of the host factor component in breast cancer etiology, as reflected in most reports in the literature, suffers from severe underestimation.
我们对先前发表的一组225例在我们肿瘤诊所接受评估的经确诊的乳腺癌患者进行了密集的医学遗传学随访。对103例新确诊的乳腺癌患者进行了类似评估，从而共有328例连续的经确诊的乳腺癌患者。我们认为，这是此类工作中为详尽记录一系列乳腺癌患者的家系及所有解剖部位癌症情况所做出的最为密集的努力之一。结果显示，在我们最初的225例乳腺癌先证者中，家族性和假定遗传性类别几乎增加了一倍。我们得出结论，正如文献中大多数报告所反映的那样，宿主因素成分在乳腺癌病因学中的影响被严重低估了。
