Garcia Mesa Karen, Bermejo Justo Lorenzo, Torres Diana, Gilbert Michael, Plass Christoph, Hamann Ute
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Onco Targets Ther. 2020 Nov 30;13:12281-12287. doi: 10.2147/OTT.S274431. eCollection 2020.
Genetic variants in microRNA (miR) binding sites affect the regulation of miR-dependent gene expression and have been linked to the risk of a variety of cancers including breast cancer (BC). Most BC risk variants had been identified in women of European and Asian ancestry, but genetic data for Hispanic women are scarce. Here, we investigate the association between six variants in miR binding sites and BC risk in Colombian women.
We genotyped miR binding site variants in the and genes in 1022 BC cases and 1023 controls from the Colombian breast cancer case-control (Col-BCCC) study using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Multiple logistic regression and permutation techniques were applied to assess the association between genetic variants and BC risk.
We found no evidence of association between any of the six miR binding site variants and overall or estrogen receptor subtype-specific BC risk in Colombian women.
Our findings may point to ethnic differences in the association between genetic variability in miR binding sites and breast cancer risk.
微小RNA（miR）结合位点的基因变异会影响miR依赖的基因表达调控，并与包括乳腺癌（BC）在内的多种癌症风险相关。大多数BC风险变异已在欧洲和亚洲血统的女性中被鉴定出来，但西班牙裔女性的基因数据却很稀少。在此，我们研究了miR结合位点的六个变异与哥伦比亚女性BC风险之间的关联。
我们使用基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）对来自哥伦比亚乳腺癌病例对照（Col-BCCC）研究的1022例BC病例和1023例对照中的和基因中的miR结合位点变异进行基因分型。应用多元逻辑回归和置换技术来评估基因变异与BC风险之间的关联。
我们没有发现哥伦比亚女性中六个miR结合位点变异中的任何一个与总体或雌激素受体亚型特异性BC风险之间存在关联的证据。
我们的研究结果可能表明miR结合位点基因变异与乳腺癌风险之间的关联存在种族差异。
