Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
Children's Health and Exercise Research Centre, Department of Public Health and Sports Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX1 2LU, UK.
J Clin Endocrinol Metab. 2023 Nov 17;108(12):3250-3259. doi: 10.1210/clinem/dgad354.
Inflammation has been associated with atherosclerosis and metabolic disorders in youth. Preventing inflammation through exposure to different accelerometer-based movement behaviors has not been longitudinally examined.
This work aimed to examine the mediating role of fat mass, lipids, and insulin resistance on the associations of cumulative sedentary time (ST), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with inflammation.
From the Avon Longitudinal Study of Parents and Children, United Kingdom, 792 children with data on at least 2 time-point measures of accelerometer-based ST, LPA, and MVPA during age 11, 15, and 24 years follow-up clinic visits with complete high-sensitivity C-reactive protein (hsCRP) measures at age 15, 17, and 24 years were studied. Mediating associations were examined using structural equation models. When the magnitude of the association between the exposure and outcome is increased after including a third variable, suppression occurred but mediation if decreased.
Among 792 (58% female; mean [SD] age at baseline, 11.7 [0.2] years), ST increased, LPA decreased, and MVPA had a U-shaped increase while hsCRP increased during 13-year follow-up. Insulin resistance partly suppressed (23.5% suppression) the positive associations of ST with hsCRP among participants who were overweight/obese. Fat mass partly mediated (30% mediation) the negative associations of LPA with hsCRP. Fat mass had a 77% mediation effect on the negative associations of MVPA with hsCRP.
ST worsens inflammation, but increased LPA had a 2-fold inflammatory-lowering effect and was more resistant to the attenuating effect of fat mass compared with MVPA, and hence should be targeted in future interventions.
炎症与年轻人的动脉粥样硬化和代谢紊乱有关。通过接触不同基于加速度计的运动行为来预防炎症尚未进行纵向研究。
本研究旨在探讨脂肪量、脂质和胰岛素抵抗对累积久坐时间（ST）、低强度体力活动（LPA）和中高强度体力活动（MVPA）与炎症之间关联的中介作用。
本研究来自英国阿冯纵向研究父母和儿童，共有 792 名儿童在 11、15 和 24 岁随访就诊期间至少有 2 次基于加速度计的 ST、LPA 和 MVPA 数据，并且在 15、17 和 24 岁时具有完整的高敏 C 反应蛋白（hsCRP）测量值。使用结构方程模型来检查中介关联。如果在纳入第三个变量后，暴露与结局之间的关联程度增加，则会发生抑制，但如果降低，则为中介。
在 792 名参与者中（58%为女性；基线时的平均[标准差]年龄为 11.7[0.2]岁），ST 增加，LPA 减少，MVPA 呈 U 型增加，而 hsCRP 在 13 年的随访期间增加。在超重/肥胖的参与者中，胰岛素抵抗部分抑制了 ST 与 hsCRP 之间的正相关（抑制 23.5%）。脂肪量部分介导（30%介导）LPA 与 hsCRP 之间的负相关。脂肪量对 MVPA 与 hsCRP 之间的负相关有 77%的介导作用。
ST 会加重炎症，但增加的 LPA 具有 2 倍的抗炎作用，并且比 MVPA 更能抵抗脂肪量的减弱作用，因此，在未来的干预中应该将其作为靶点。
