潜在的卤代工业致癌和致突变化学物质。I. 卤代不饱和烃。

Potential halogenated industrial carcinogenic and mutagenic chemicals. I. Halogenated unsaturated hydrocarbons.

作者信息

Fishbein L

出版信息

Sci Total Environ. 1979 Mar;11(2):111-61. doi: 10.1016/0048-9697(79)90025-1.

Abstract

The halogenated aliphatic hydrocarbons represent one of the most important categories of industrial chemicals from a consideration of use categories, production volume, environmental and toxicological considerations, and hence most importantly, potential population risk. The major unsaturated hydrocarbons reviewed, primarily in terms of their synthesis, utility, stability, distribution and levels of exposure as well as their reactivity, carcinogenicity, mutagenicity and metabolism, include: vinyl chloride, vinylidene chloride, trichloroethylene, perchloroethylene, chloroprene, trans-1,4-dichlorobutene, hexachlorobutadiene and allyl chloride.

摘要

从使用类别、产量、环境和毒理学考量，以及因此最重要的潜在人群风险来看，卤代脂肪烃是最重要的工业化学品类别之一。所综述的主要不饱和烃，主要涉及其合成、用途、稳定性、分布和暴露水平以及它们的反应性、致癌性、致突变性和代谢，包括：氯乙烯、偏二氯乙烯、三氯乙烯、全氯乙烯、氯丁二烯、反式-1,4-二氯丁烯、六氯丁二烯和烯丙基氯。