Tan R S, Chen Y Q, Fan Z F, Liu S Z, Zhang Y H
Cancer Detect Prev. 1986;9(1-2):145-9.
Many biochemical parameters have been used as tumor markers but few are satisfactory to reflect tumor diathesis and/or for early detection. Studies in the Cancer Institute, Chinese Academy of Medical Sciences, have indicated that serum alpha 1-acid glycoprotein and sialic acid were increased in lung cancers, but 20% of pulmonary tuberculosis patients were also positive. Serum polyamines determined by RIA were increased in cancer patients. The positive rates for cancer of lung and esophagus were 84% and 100%, respectively. Polyamine contents considerably increased in esophagus tissue of rats treated with methylbenzylnitrosamine, and this occurred far earlier than the tumor appeared. However, whether serum polyamine can be used for early detection of esophageal cancer awaits further studies. An unknown fluorescent compound in urine was found in normal people but was very much decreased in cancer patients. This compound showed cytostatic effect on tumor cells in vitro. Serum antibodies against EBV-associated DNase could be used as a marker for NPC.
许多生化参数已被用作肿瘤标志物，但很少有能令人满意地反映肿瘤素质和/或用于早期检测的。中国医学科学院肿瘤研究所的研究表明，肺癌患者血清α1-酸性糖蛋白和唾液酸升高，但20%的肺结核患者也呈阳性。用放射免疫分析法测定的癌症患者血清多胺升高。肺癌和食管癌的阳性率分别为84%和100%。用甲基苄基亚硝胺处理的大鼠食管组织中多胺含量显著增加，且这一现象远早于肿瘤出现。然而，血清多胺是否可用于食管癌的早期检测有待进一步研究。在正常人尿液中发现一种未知的荧光化合物，而癌症患者尿液中该化合物含量则大幅降低。这种化合物在体外对肿瘤细胞有抑制作用。抗EB病毒相关脱氧核糖核酸酶的血清抗体可用作鼻咽癌的标志物。
