单克隆抗体OX7在SL2和SL1淋巴瘤中定位的部位相关差异。
Site-related differences in the localization of the monoclonal antibody OX7 in SL2 and SL1 lymphomas.
作者信息
Sands H, Jones P L, Neacy W P, Shah S A, Gallagher B M
出版信息
Cancer Immunol Immunother. 1986;22(3):169-75. doi: 10.1007/BF00200028.
The uptake of a monoclonal antibody (OX7) by murine lymphomas (SL1, SL2) growing in two sites in the mouse were compared. SL2 tumors grown in the subrenal site showed greater specific antibody uptake than did the same tumor grown in the subcutaneous site. Major differences in membrane bound antibody, in vitro antibody binding patterns, and gamma scintillation camera imaging were also observed between the two sites. These differences may be due to the greater blood flow measured in tumors growing in the subrenal capsule than those growing at the subcutaneous site. The differences observed in antibody uptake of the same tumor growing in two different sites raises questions concerning the choice of animal model systems that can be used to predict clinical utility.
比较了在小鼠两个部位生长的鼠淋巴瘤（SL1、SL2）对单克隆抗体（OX7）的摄取情况。生长在肾下部位的SL2肿瘤比生长在皮下部位的同一肿瘤表现出更高的特异性抗体摄取。在两个部位之间还观察到膜结合抗体、体外抗体结合模式和γ闪烁相机成像的主要差异。这些差异可能是由于在肾包膜下生长的肿瘤比皮下部位生长的肿瘤测量到的血流量更大。在两个不同部位生长的同一肿瘤的抗体摄取差异引发了关于可用于预测临床效用的动物模型系统选择的问题。
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