Hosokawa M, Mizukoshi T, Morikawa K, Xu Z Y, Kobayashi H
Cancer Immunol Immunother. 1986;22(3):181-5. doi: 10.1007/BF00200030.
We investigated the therapeutic effects of an immunopotentiator PS-K on recurrent or metastatic tumors observed after the surgical removal of MCA-induced primary tumors in autochthonous C57BL/6 mice and on the survival time of treated mice. The MST of mice treated with PS-K at various times (59.8-63.4 days) was prolonged as compared with that of mice treated by surgery alone (48.6 days). Local recurrence of tumors was found in 36 of 66 mice (54.6%) treated by surgery alone, whereas it was inhibited significantly (P less than 0.05) when treatment with PS-K was started 1 day after the surgery and occurred in 22 of 64 mice (34.4%) when PS-K was given for 5 days in 1 week, or in 22 of 66 mice (33.3%) when PS-K was administered twice a week for 7 weeks. The MSTs of mice with local recurrence were also found to be prolonged as compared with those of mice treated by surgery alone (54.8-67.5 days vs 49.8 days). The MSTs of mice without tumor recurrence were also prolonged significantly (P less than 0.05-0.001) by combinations of PS-K at various times, although most of the mice died of metastatic tumors even in the groups of mice where a combined treatment with PS-K had been administered. The above findings suggest that the administration of PS-K inhibits the growth of recurrent or metastatic tumor cells in autochthonous mice after the surgical removal of the primary tumors.
我们研究了免疫增强剂PS-K对同源C57BL/6小鼠MCA诱导的原发性肿瘤手术切除后观察到的复发性或转移性肿瘤的治疗效果，以及对治疗小鼠存活时间的影响。与仅接受手术治疗的小鼠（48.6天）相比，在不同时间接受PS-K治疗的小鼠的中位生存时间（MST）延长（59.8 - 63.4天）。仅接受手术治疗的66只小鼠中有36只（54.6%）出现肿瘤局部复发，而在手术后1天开始使用PS-K治疗时，肿瘤局部复发受到显著抑制（P小于0.05），当PS-K每周给药5天，持续1周时，64只小鼠中有22只（34.4%）出现肿瘤局部复发，或者当PS-K每周给药两次，持续7周时，66只小鼠中有22只（33.3%）出现肿瘤局部复发。与仅接受手术治疗的小鼠相比，出现局部复发的小鼠的MST也延长了（54.8 - 67.5天对49.8天）。尽管在接受PS-K联合治疗的小鼠组中，大多数小鼠死于转移性肿瘤，但在不同时间联合使用PS-K也显著延长了无肿瘤复发小鼠的MST（P小于0.05 - 0.001）。上述发现表明，给予PS-K可抑制原发性肿瘤手术切除后同源小鼠中复发性或转移性肿瘤细胞的生长。
