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奥洛他定与酮替芬治疗过敏性结膜炎的比较：一项荟萃分析研究。

Comparison of olopatadine with ketotifen for allergic conjunctivitis: a meta-analysis study.

作者信息

Li Shiyu, Zhong Shenquan

机构信息

Department of Ophthalmology, The First People's Hospital of Chongqing Liangjiang New Area, Chongqing, China.

出版信息

Postepy Dermatol Alergol. 2023 Apr;40(2):326-330. doi: 10.5114/ada.2023.127647. Epub 2023 May 31.

DOI:10.5114/ada.2023.127647
PMID:37312902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10258714/
Abstract

INTRODUCTION

Allergic conjunctivitis is one of the most common non-traumatic extraocular inflammatory diseases.

AIM

The comparison of olopatadine with ketotifen remains elusive for the treatment of allergic conjunctivitis, and this meta-analysis aims to explore the impact of olopatadine versus ketotifen on treatment efficacy for allergic conjunctivitis.

MATERIAL AND METHODS

PubMed, Embase, Web of Science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of olopatadine versus ketotifen on efficacy in patients with allergic conjunctivitis. Seven RCTs were included in the meta-analysis.

RESULTS

Overall, compared with ketotifen intervention for allergic conjunctivitis, olopatadine intervention was associated with substantially lower hyperaemia (mean difference (MD) = -0.77; 95% confidence interval (CI) = -1.24 to -0.30; = 0.001), but demonstrated no significant impact on itching, tearing or papillae.

CONCLUSIONS

These suggested that olopatadine may be more effective to relieve the symptoms of allergic conjunctivitis than ketotifen.

摘要

引言

过敏性结膜炎是最常见的非创伤性眼外炎症性疾病之一。

目的

在过敏性结膜炎的治疗中，奥洛他定与酮替芬的比较尚无定论，本荟萃分析旨在探讨奥洛他定与酮替芬对过敏性结膜炎治疗效果的影响。

材料与方法

系统检索了PubMed、Embase、Web of Science、EBSCO和Cochrane图书馆数据库，纳入评估奥洛他定与酮替芬对过敏性结膜炎患者疗效影响的随机对照试验（RCT）。荟萃分析纳入了7项RCT。

结果

总体而言，与酮替芬干预过敏性结膜炎相比，奥洛他定干预导致的结膜充血明显更少（平均差值（MD）=-0.77；95%置信区间（CI）=-1.24至-0.30；P=0.001），但对瘙痒、流泪或乳头增生无显著影响。

结论

这些结果表明，奥洛他定在缓解过敏性结膜炎症状方面可能比酮替芬更有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/65f013b7fd6b/PDIA-40-50721-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/a7ec05c149e3/PDIA-40-50721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/08184e3cc185/PDIA-40-50721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/c26d9aafed8b/PDIA-40-50721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/85d603dfa3f2/PDIA-40-50721-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/65f013b7fd6b/PDIA-40-50721-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/a7ec05c149e3/PDIA-40-50721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/08184e3cc185/PDIA-40-50721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/c26d9aafed8b/PDIA-40-50721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/85d603dfa3f2/PDIA-40-50721-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1995/10258714/65f013b7fd6b/PDIA-40-50721-g005.jpg

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本文引用的文献

1
Brazilian guidelines for the monitoring and treatment of pediatric allergic conjunctivitis.巴西儿童过敏性结膜炎监测和治疗指南。
Arq Bras Oftalmol. 2021 Nov 29;85(4):415-425. doi: 10.5935/0004-2749.20220053. eCollection 2021.
2
Airborne Pollens and Their Association with Meteorological Parameters in the Atmosphere of Shiraz, Southwest Iran.伊朗西南部设拉子市大气中的气载花粉及其与气象参数的关系。
Iran J Allergy Asthma Immunol. 2021 Jun 6;20(3):294-302. doi: 10.18502/ijaai.v20i3.6332.
3
Development of allergic conjunctivitis induced by excretory-secretory protein and the effect of resolvin D1 on treatment.
过敏性结膜炎的发生与外分泌蛋白的关系及解析素 D1 的治疗作用
Curr Eye Res. 2021 Dec;46(12):1792-1799. doi: 10.1080/02713683.2021.1934878. Epub 2021 Jul 26.
4
Current Knowledge in Allergic Conjunctivitis.变应性结膜炎的当前知识。
Turk J Ophthalmol. 2021 Feb 25;51(1):45-54. doi: 10.4274/tjo.galenos.2020.11456.
5
Use of allergen immunotherapy for treatment of allergic conjunctivitis.变应原免疫治疗用于治疗过敏性结膜炎。
Curr Opin Allergy Clin Immunol. 2020 Dec;20(6):609-615. doi: 10.1097/ACI.0000000000000692.
6
Chemokines in allergic conjunctivitis.变应性结膜炎中的趋化因子
Curr Opin Allergy Clin Immunol. 2020 Oct;20(5):516-527. doi: 10.1097/ACI.0000000000000676.
7
Allergic conjunctivitis in children: current understanding and future perspectives.儿童过敏性结膜炎：当前认识与未来展望。
Curr Opin Allergy Clin Immunol. 2020 Oct;20(5):507-515. doi: 10.1097/ACI.0000000000000675.
8
Epidemiological aspects of allergic conjunctivitis.过敏性结膜炎的流行病学方面。
Allergol Int. 2020 Oct;69(4):487-495. doi: 10.1016/j.alit.2020.06.004. Epub 2020 Jul 9.
9
ICON: Diagnosis and management of allergic conjunctivitis.ICON：过敏性结膜炎的诊断与管理。
Ann Allergy Asthma Immunol. 2020 Feb;124(2):118-134. doi: 10.1016/j.anai.2019.11.014. Epub 2019 Nov 21.
10
Diagnosing and managing allergic conjunctivitis in childhood: The allergist's perspective.诊断和管理儿童变应性结膜炎：过敏学家的观点。
Pediatr Allergy Immunol. 2019 Jun;30(4):405-414. doi: 10.1111/pai.13035.