Ali Hirowati, Tofrizal Tofrizal, Tjong Djong Hon, Yanis Amel, Yarni Sisca Dwi
Department of Biochemistry, Faculty of Medicine, Andalas University, Indonesia.
Biomedical Laboratory, Center for Integrative Biomedical Research, Andalas University, Indonesia.
Arch Med Sci. 2023 May 24;19(3):820-824. doi: 10.5114/aoms/163353. eCollection 2023.
Our study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer's disease (AD).
Twenty male adult Wistar rats were randomly distributed into three groups of animals ( = 5). The AlCl group was given 300 mg/kg body weight (BW) of AlCl intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed.
MSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group.
MSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model.
我们的研究旨在观察间充质干细胞（MSCs）在降低淀粉样蛋白积累和兰尼碱受体3（RYR3）基因表达方面的作用，进一步改善阿尔茨海默病（AD）的认知功能障碍。
将20只成年雄性Wistar大鼠随机分为三组（每组n = 5）。AlCl组腹腔注射300 mg/kg体重的AlCl，持续5天，之后注射MSCs，并观察30天后的效果。
与对照组相比，MSCs改善了淀粉样蛋白积累和Y迷宫得分，且RYR3基因的表达降低。
在AD动物模型中，MSCs改善了淀粉样蛋白积累、Y迷宫得分和RYR3表达。
