Musaeus Christian Sandøe, Gleerup Helena Sophia, Hasselbalch Steen Gregers, Waldemar Gunhild, Simonsen Anja Hviid
Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
J Alzheimers Dis Rep. 2023 Jun 2;7(1):535-541. doi: 10.3233/ADR-230016. eCollection 2023.
Studies have found a disruption of the blood-brain barrier (BBB) in patients with Alzheimer's disease (AD), but there is little evidence of the changes in the BBB over time. The cerebrospinal fluid's (CSF) protein concentration can be used as an indirect measurement for the permeability of the BBB using the CSF/plasma albumin quotient (Q-Alb) or total CSF protein.
In the current study, we wanted to investigate the changes in Q-Alb in patients with AD over time.
A total of 16 patients diagnosed with AD, who had at least two lumbar punctures performed, were included in the current study.
The difference in Q-Alb over time did not show a significant change. However, Q-Alb increased over time if the time interval was > 1 year between the measurements. No significant associations between Q-Alb and age, Mini-Mental State Examination, or AD biomarkers were found.
The increase in Q-Alb suggests that there is an increased leakage through the BBB, which may become more prominent as the disease progresses. This may be a sign of progressive underlying vascular pathology, even in patients with AD without major vascular lesions. More studies are needed to further understand the role of BBB integrity in patients with AD over time and the association with the progression of the disease.
研究发现阿尔茨海默病（AD）患者存在血脑屏障（BBB）破坏，但几乎没有证据表明血脑屏障随时间发生变化。脑脊液（CSF）蛋白浓度可通过脑脊液/血浆白蛋白商（Q-Alb）或脑脊液总蛋白作为血脑屏障通透性的间接测量指标。
在本研究中，我们想调查AD患者Q-Alb随时间的变化。
本研究纳入了16例诊断为AD且至少进行过两次腰椎穿刺的患者。
Q-Alb随时间的差异未显示出显著变化。然而，如果两次测量之间的时间间隔>1年，Q-Alb会随时间增加。未发现Q-Alb与年龄、简易精神状态检查或AD生物标志物之间存在显著关联。
Q-Alb升高表明血脑屏障的渗漏增加，随着疾病进展可能会更加明显。这可能是潜在血管病变进展的迹象，即使在没有主要血管病变的AD患者中也是如此。需要更多研究来进一步了解血脑屏障完整性在AD患者随时间变化中的作用以及与疾病进展的关联。
