Skillbäck Tobias, Delsing Louise, Synnergren Jane, Mattsson Niklas, Janelidze Shorena, Nägga Katarina, Kilander Lena, Hicks Ryan, Wimo Anders, Winblad Bengt, Hansson Oskar, Blennow Kaj, Eriksdotter Maria, Zetterberg Henrik
Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Systems Biology Research Center, School of Bioscience, University of Skövde, Skövde, Sweden.
Neurobiol Aging. 2017 Nov;59:1-9. doi: 10.1016/j.neurobiolaging.2017.06.028. Epub 2017 Jul 11.
A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362), Lewy body dementia (DLB, n = 50), frontotemporal dementia (FTD, n = 56), Parkinson's disease dementia (PDD, n = 23), other dementias (other, n = 48), and dementia not otherwise specified (NOS, n = 271). We compared CSF/serum albumin ratio to 2 healthy control groups (n = 292, n = 20), between dementia diagnoses, and tested biomarker associations. Patients in DLB, LAD, VaD, MIX, other, and NOS groups had higher CSF/serum albumin ratio than controls. CSF/serum albumin ratio correlated with CSF neurofilament light in LAD, MIX, VaD, and other groups but not with AD biomarkers. Our data show that BBB leakage is common in dementias. The lack of association between CSF/serum albumin ratio and AD biomarkers suggests that BBB dysfunction is not inherent to AD but might represent concomitant cerebrovascular pathology.
痴呆症与血脑屏障（BBB）功能障碍之间的联系已被提出，但先前的研究结果相互矛盾。我们在一大群被诊断患有阿尔茨海默病（AD，早发型[EAD，n = 130]，晚发型AD[LAD，n = 666]）、血管性痴呆（VaD，n = 255）、AD与VaD混合型（MIX，n = 362）、路易体痴呆（DLB，n = 50）、额颞叶痴呆（FTD，n = 56）、帕金森病痴呆（PDD，n = 23）、其他痴呆症（其他，n = 48）以及未另行指定的痴呆症（NOS，n = 271）的患者中检测了脑脊液（CSF）/血清白蛋白比值。我们将CSF/血清白蛋白比值与两个健康对照组（n = 292，n = 20）进行比较，比较不同痴呆症诊断之间的情况，并测试生物标志物之间的关联。DLB、LAD、VaD、MIX、其他和NOS组的患者CSF/血清白蛋白比值高于对照组。CSF/血清白蛋白比值在LAD、MIX、VaD和其他组中与CSF神经丝轻链相关，但与AD生物标志物无关。我们的数据表明，BBB渗漏在痴呆症中很常见。CSF/血清白蛋白比值与AD生物标志物之间缺乏关联表明，BBB功能障碍并非AD所固有，而是可能代表伴随的脑血管病变。
