[Oncological alertness in Graves disease].

OBJECTIVE

To assess the risk of thyroid cancer in patients with Graves' disease (GD) after surgical treatment.

MATERIAL AND METHODS

We retrospectively evaluated 121 patients with GD after thyroidectomy between December 2015 and January 2020. Thyroid cancer was confirmed by morphological analysis. Thyroid cancer occurred in 34 (28.1%) patients with GD after thyroidectomy. Preoperative ultrasound examination revealed nodular goiter in 62 (51.2%) patients. Nodular lesions were not found in other 59 (48.8%) patients with GD.

RESULTS

Incidence of thyroid cancer was significantly higher in patients with nodular lesions (38% vs. 16%; =0.009). Papillary thyroid cancer was detected in 32 out of 34 cases, follicular thyroid cancer - in 2 patients. Among 32 patients with papillary thyroid cancer, 28 ones had classical type, 2 patients - follicular variant of papillary cancer, 1 patient - oncocytic cancer, 1 patient - columnar cell variant of PTC.

CONCLUSION

Risk of cancer is higher in patients with GD and nodes. In addition to standard examination of patients with GD, we performed ultrasound with examination of regional lymph nodes and analysis of further surgical tactics.