Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Spitalstrasse 2, 4056 Basel, Switzerland.
Cardiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031 Basel, Switzerland.
Europace. 2023 Jun 2;25(6). doi: 10.1093/europace/euad149.
Atrial remodelling, defined as a change in atrial structure, promotes atrial fibrillation (AF). Bone morphogenetic protein 10 (BMP10) is an atrial-specific biomarker released to blood during atrial development and structural changes. We aimed to validate whether BMP10 is associated with AF recurrence after catheter ablation (CA) in a large cohort of patients.
We measured baseline BMP10 plasma concentrations in AF patients who underwent a first elective CA in the prospective Swiss-AF-PVI cohort study. The primary outcome was AF recurrence lasting longer than 30 s during a follow-up of 12 months. We constructed multivariable Cox proportional hazard models to determine the association of BMP10 and AF recurrence. A total of 1112 patients with AF (age 61 ± 10 years, 74% male, 60% paroxysmal AF) was included in our analysis. During 12 months of follow-up, 374 patients (34%) experienced AF recurrence. The probability for AF recurrence increased with increasing BMP10 concentration. In an unadjusted Cox proportional hazard model, a per-unit increase in log-transformed BMP10 was associated with a hazard ratio (HR) of 2.28 (95% CI 1.43; 3.62, P < 0.001) for AF recurrence. After multivariable adjustment, the HR of BMP10 for AF recurrence was 1.98 (95% CI 1.14; 3.42, P = 0.01), and there was a linear trend across BMP10 quartiles (P = 0.02 for linear trend).
The novel atrial-specific biomarker BMP10 was strongly associated with AF recurrence in patients undergoing CA for AF.
CLINICALTRIALS.GOV IDENTIFIER: NCT03718364; https://clinicaltrials.gov/ct2/show/NCT03718364.
心房重构定义为心房结构的变化，可促进心房颤动（房颤）的发生。骨形态发生蛋白 10（BMP10）是一种在心房发育和结构变化过程中释放到血液中的心房特异性生物标志物。我们旨在通过对大量患者进行研究，验证 BMP10 是否与导管消融（CA）后房颤复发相关。
我们在前瞻性瑞士房颤消融-肺静脉隔离（Swiss-AF-PVI）队列研究中，测量了首次接受择期 CA 的房颤患者的基线 BMP10 血浆浓度。主要终点是在 12 个月的随访中持续时间超过 30s 的房颤复发。我们构建了多变量 Cox 比例风险模型，以确定 BMP10 与房颤复发的关系。共纳入 1112 例房颤患者（年龄 61±10 岁，74%为男性，60%为阵发性房颤）进行分析。在 12 个月的随访中，374 例患者（34%）发生房颤复发。BMP10 浓度升高，房颤复发的可能性增加。在未校正的 Cox 比例风险模型中，log 转换后的 BMP10 每增加一个单位，房颤复发的风险比（HR）为 2.28（95%CI 1.43；3.62，P<0.001）。经过多变量调整后，BMP10 与房颤复发的 HR 为 1.98（95%CI 1.14；3.42，P=0.01），且 BMP10 四分位间距存在线性趋势（P=0.02）。
新型心房特异性生物标志物 BMP10 与接受 CA 治疗的房颤患者房颤复发密切相关。
NCT03718364；https://clinicaltrials.gov/ct2/show/NCT03718364。
Zotero 插件
