从 Gallinarum 到 Typhimurium 的 T6SS 转移弥补了缺乏 T6SS 补体的 Typhimurium 在小鼠中的定植缺陷。
Transfer of T6SS from Gallinarum to Typhimurium Lacking T6SS Complements its Colonization Defect in Mice.
机构信息
1Núcleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronómicas, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Santiago, Chile.
2Departamento de Ciencias Químicas y Biológicas, Universidad Bernardo O'Higgins, Santiago, Chile.
出版信息
Pol J Microbiol. 2023 Jun 14;72(2):215-219. doi: 10.33073/pjm-2023-017. eCollection 2023 Jun 1.
genus harbors five Type VI Secretion System (T6SS) gene clusters. The T6SS encoded in SPI-6 (T6SS) contributes to Typhimurium colonization of chickens and mice, while the T6SS encoded in SPI-19 (T6SS) of Gallinarum contributes to chicken colonization. Interestingly, the T6SS of Gallinarum complemented the defect in chicken colonization of a Typhimurium strain that lacks the T6SS, suggesting that both T6SSs are interchangeable. Here we show that the transfer of Gallinarum T6SS complemented the defect in mice colonization of a Typhimurium ΔT6SS strain, indicating that both T6SSs are functionally redundant during host colonization.
该属包含五个类型 VI 分泌系统（T6SS）基因簇。SPI-6 编码的 T6SS（T6SS）有助于鼠伤寒沙门氏菌对鸡和小鼠的定殖，而 Gallinarum 编码的 SPI-19（T6SS）有助于鸡的定殖。有趣的是，Gallinarum 的 T6SS 弥补了缺乏 T6SS 的鼠伤寒沙门氏菌菌株在鸡定殖中的缺陷，表明这两种 T6SS 是可互换的。在这里，我们表明 Gallinarum 的 T6SS 的转移弥补了鼠伤寒沙门氏菌 ΔT6SS 菌株在小鼠定殖中的缺陷，表明这两种 T6SS 在宿主定殖过程中具有功能冗余性。
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