Laboratorio de Morfofisiología, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Camino Ing. Ramón Padilla Sánchez No 2100, Predio las Agujas, C.P. 45510, Zapopan, Nextipac, Jalisco, Mexico.
Laboratorio de Biomarcadores Moleculares en Biomedicina y Ecología, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Camino Ing. Ramón Padilla Sánchez No 2100, Predio las Agujas, C.P. 45510, Zapopan, Nextipac, Jalisco, Mexico.
Plant Foods Hum Nutr. 2023 Jun;78(2):426-431. doi: 10.1007/s11130-023-01061-x. Epub 2023 Jun 14.
The calyxes of Hibiscus sabdariffa present multiple pharmacological effects primarily attributed to their high anthocyanin content; however, little is known about their phytoestrogenic effect. Ovarian hypofunction (OH) is a process characterized by the rapid detention of the production of ovarian hormones, which compromises reproductive and cognitive functions. Hormone replacement therapy (HRT) efficiently compensates for OH; nevertheless, questions have been raised on its secondary effects and safety. One of the alternatives to tackling OH involves using phytoestrogens such as anthocyanins for their structural similarity to natural estrogens. In a Wistar rat model of ovariectomy (OVX), we recently reported the beneficial properties of an anthocyanin-rich extract prepared from the calyces of H. sabdariffa (HSE) in hindering the adverse effects of OH on memory performance and highlighted a possible phytoestrogenic impact through the modulation of estrogen receptor (ER) expression. We now report that HSE and estradiol differentially affected the expression of ERα and ERβ. ERα was more sensitive to HSE; meanwhile, estradiol preferentially modulated ERβ. Thus, our study leads to further research on using H. sabdariffa as a nutrition-based alternative to HRT.
鸡冠花的花萼具有多种药理作用，主要归因于其高含量的花色苷；然而，其植物雌激素作用知之甚少。卵巢功能减退（OH）是一个卵巢激素产生迅速停止的过程，会影响生殖和认知功能。激素替代疗法（HRT）有效地弥补了 OH；然而，人们对其副作用和安全性提出了质疑。解决 OH 的方法之一是使用植物雌激素，如花色苷，因为它们与天然雌激素的结构相似。在卵巢切除术（OVX）的 Wistar 大鼠模型中，我们最近报道了从鸡冠花（Hibiscus sabdariffa）花萼中制备的富含花色苷的提取物（HSE）在阻止 OH 对记忆性能的不良影响方面的有益特性，并通过调节雌激素受体（ER）表达强调了其可能的植物雌激素作用。我们现在报告说，HSE 和雌二醇对 ERα和 ERβ的表达有不同的影响。ERα对 HSE 更敏感；而雌二醇则优先调节 ERβ。因此，我们的研究促使进一步研究使用鸡冠花作为 HRT 的基于营养的替代物。
