Exercise Physiology and Neurobiology Lab, College of Physical Education and Sports, Beijing Normal University, Beijing 100875, China.
College of Chemistry, Beijing Normal University, Beijing 100875, China.
ACS Chem Neurosci. 2023 Jul 5;14(13):2443-2449. doi: 10.1021/acschemneuro.3c00185. Epub 2023 Jun 14.
Fatigue is a common symptom in neurological diseases with a complex cause, involving the influence of events occurring in both the central and peripheral nervous systems. When people suffer from fatigue, a general decline in their movement performance typically occurs. The neural representation of dopamine signaling in the striatum plays a crucial role in movement regulation. Movement vigor is regulated by dopamine-dependent neuron activity in the striatum. However, whether exercise-induced fatigue alters stimulated dopamine release and further affects movement vigor has not been described. Here, for the first time, we used fast-scan cyclic voltammetry to demonstrate the effect of exercise-induced fatigue on stimulated dopamine release in the striatum in combination with a fiber photometry system to observe the excitability of striatal neurons. The movement vigor of mice was reduced, and after fatigue, the balance of excitability of striatal neurons regulated by dopamine projections was disturbed, which was induced by a reduction in dopamine release. Additionally, D2DR regulation may serve as a targeted intervention to alleviate exercise-induced fatigue and promote fatigue recovery.
疲劳是一种常见的神经系统疾病症状，其病因复杂，涉及中枢和外周神经系统事件的影响。当人们感到疲劳时，通常会出现运动表现全面下降的情况。纹状体中多巴胺信号的神经表现对于运动调节起着至关重要的作用。运动活力受纹状体内多巴胺依赖性神经元活动的调节。然而，运动引起的疲劳是否会改变刺激的多巴胺释放，并进一步影响运动活力，尚未有相关描述。在这里，我们首次使用快速扫描循环伏安法结合光纤光度测定系统来证明运动诱导的疲劳对纹状体中刺激的多巴胺释放的影响，以观察纹状体内神经元的兴奋性。结果表明，运动疲劳后，小鼠的运动活力降低，多巴胺投射调节的纹状体内神经元兴奋性平衡被打乱，这是由多巴胺释放减少引起的。此外，D2DR 调节可能作为一种靶向干预措施，以减轻运动诱导的疲劳并促进疲劳恢复。
