癌症免疫脱轨：PGE 使 cDC1 失常。

Cancer immunity derailed: PGE misconducts cDC1s.

机构信息

Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Extramural Member, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.

出版信息

Immunity. 2023 Jun 13;56(6):1165-1167. doi: 10.1016/j.immuni.2023.05.015.

DOI:10.1016/j.immuni.2023.05.015

PMID:37315532

Abstract

Type 1 conventional dendritic cells (cDC1s) are critical for CD8 T cell-mediated tumor control. In this issue of Immunity, Bayerl et al. expose a mechanism leading to cancer progression where prostaglandin E induces dysfunctional cDC1s, which cannot coordinate CD8 T cell migration and expansion.

摘要

1 型传统树突状细胞（cDC1）对于 CD8 T 细胞介导的肿瘤控制至关重要。在本期《免疫》杂志中，Bayerl 等人揭示了一种导致癌症进展的机制，即前列腺素 E 诱导功能性失调的 cDC1，使其无法协调 CD8 T 细胞的迁移和扩增。