肿瘤 NOS2 和 COX2 与 CD8+T 细胞的空间毗邻促进转移和癌症干细胞生态位形成，导致 ER- 乳腺癌不良预后。
Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.
机构信息
Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.
Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
出版信息
Cancer Res Commun. 2024 Oct 1;4(10):2766-2782. doi: 10.1158/2767-9764.CRC-24-0235.
Abstract
This work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically available NOS inhibitors and NSAIDs.
摘要
这项工作鉴定了 CD8-NOS2+COX2+ 和 CD8-NOS2-COX2+ 独特的细胞小区，这些小区驱动了 CD8+T 细胞的肿瘤免疫空间结构，预测了临床结果，可以用临床可用的 NOS 抑制剂和 NSAIDs 进行靶向治疗。
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