Newlife IVF, Melbourne, Victoria, Australia.
Royal Women's Hospital, Melbourne, Victoria, Australia.
Aust N Z J Obstet Gynaecol. 2023 Dec;63(6):774-779. doi: 10.1111/ajo.13721. Epub 2023 Jun 14.
The presence of different breast cancer receptor status may impact ovarian stimulation outcomes.
To study the association between oestrogen receptor (ER) status in breast cancer patients and fertility preservation outcomes in a major tertiary referral centre.
Women who underwent fertility preservation following the diagnosis of breast cancer from 2008 to 2018 were included in the study. Patient age, ovarian stimulation parameters and laboratory outcomes were recorded and compared between the ER positive and negative groups. The primary outcome was total number of oocytes frozen. Secondary outcomes included total number of oocytes collected, mature oocytes, and embryos frozen.
The women included in the study (n = 214) were analysed in the following groups based on their fertility preservation method: oocyte freezing (n = 131), embryo freezing (n = 70), and both embryo and oocyte freezing (n = 13). There was an increase in the mean (but not mature) number of oocytes frozen (12.4 and 9.2, P-value = 0.03) favouring the ER positive group, even though the women in this group were older (35.0 and 33.4, P-value of 0.03). There is no difference in the starting follicle-stimulating hormone dose, duration of stimulation, mature oocytes collected, and embryos frozen in both groups.
Patients with ER positive breast cancer may have more positive ovarian stimulation outcomes.
不同的乳腺癌受体状态可能会影响卵巢刺激的结果。
研究在一家主要的三级转诊中心中，乳腺癌患者的雌激素受体（ER）状态与生育保存结果之间的关系。
本研究纳入了 2008 年至 2018 年间诊断为乳腺癌后进行生育保存的女性。记录患者年龄、卵巢刺激参数和实验室结果，并比较 ER 阳性和阴性组之间的差异。主要结局是冷冻的卵母细胞总数。次要结局包括采集的卵母细胞总数、成熟卵母细胞和冷冻胚胎数。
根据生育保存方法，对纳入研究的 214 名女性进行了如下分组分析：卵母细胞冷冻（n=131）、胚胎冷冻（n=70）和胚胎及卵母细胞冷冻（n=13）。ER 阳性组冷冻的卵母细胞数量（12.4 和 9.2，P 值=0.03），即使该组女性年龄较大（35.0 和 33.4，P 值=0.03），但平均值（而非成熟）有所增加。两组的起始卵泡刺激素剂量、刺激持续时间、采集的成熟卵母细胞和冷冻胚胎数均无差异。
ER 阳性乳腺癌患者可能有更积极的卵巢刺激结果。
