门控反射是神经回路，可建立免疫细胞的门控，以调节组织特异性炎症。

Gateway reflexes are neural circuits that establish the gateway of immune cells to regulate tissue specific inflammation.

机构信息

Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Group of Quantum Immunology, Institute for Quantum Life Science, National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan.

出版信息

Expert Opin Ther Targets. 2023 Jan-Jun;27(6):469-477. doi: 10.1080/14728222.2023.2225215. Epub 2023 Jun 20.

DOI:10.1080/14728222.2023.2225215

PMID:37318003

Abstract

INTRODUCTION

Tissue-specific inflammatory diseases are regulated by several mechanisms. The gateway reflex and IL-6 amplifier are two mechanisms involved in diseases that depend on the inflammatory cytokine IL-6. The gateway reflex activates specific neural pathways that cause autoreactive CD4+ T cells to pass through gateways in blood vessels toward specific tissues in tissue-specific inflammatory diseases. These gateways are mediated by the IL-6 amplifier, which describes enhanced NF-κB activation in nonimmune cells including endothelial cells at specific sites. In total, we have reported six gateway reflexes defined by their triggering stimulus: gravity, pain, electric stimulation, stress, light, and joint inflammation.

AREAS COVERED

This review summarizes the gateway reflex and IL-6 amplifier for the development of tissue-specific inflammatory diseases.

EXPERT OPINION

We expect that the IL-6 amplifier and gateway reflex will lead to novel therapeutic and diagnostic methods for inflammatory diseases, particularly tissue-specific ones.

摘要

简介

组织特异性炎症性疾病受多种机制调控。门控反射和 IL-6 放大器是两种与依赖炎症细胞因子 IL-6 的疾病相关的机制。门控反射激活特定的神经通路，导致自身反应性 CD4+T 细胞穿过血管中的门控，向组织特异性炎症性疾病中的特定组织移动。这些门控由 IL-6 放大器介导，该放大器描述了特定部位的非免疫细胞（包括内皮细胞）中 NF-κB 激活的增强。总的来说，我们已经报道了六个由触发刺激定义的门控反射：重力、疼痛、电刺激、应激、光照和关节炎症。