催乳素对免疫系统的影响、与 COVID-19 严重程度的关系及其潜在的免疫调节治疗作用。
The effects of prolactin on the immune system, its relationship with the severity of COVID-19, and its potential immunomodulatory therapeutic effect.
机构信息
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Department of Bioinformatics and Genetics, School of Engineering and Natural Sciences, Kadir Has University 34083, Cibali Campus Fatih, Istanbul, Turkey.
出版信息
Cytokine. 2023 Sep;169:156253. doi: 10.1016/j.cyto.2023.156253. Epub 2023 Jun 7.
Prolactin (PRL) is an endocrine hormone secreted by the anterior pituitary gland that has a variety of physiological effects, including milk production, immune system regulation, and anti-inflammatory effects. Elevated levels of PRL have been found in several viral infections, including 2019 coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), a viral pathogen that has recently spread worldwide. PRL production is increased in SARS-CoV2 infection. While PRL can trigger the production of proinflammatory cytokines, it also has several anti-inflammatory effects that can reduce hyperinflammation. The exact mechanism of PRL's contribution to the severity of COVID-19 is unknown. The purpose of this review is to discuss the interaction between PRL and SARS-CoV2 infection and its possible association with the severity of COVID-19.
催乳素（PRL）是由垂体前叶分泌的一种内分泌激素，具有多种生理作用，包括产奶、免疫系统调节和抗炎作用。在几种病毒感染中发现催乳素水平升高，包括由严重急性呼吸综合征冠状病毒 2（SARS-CoV2）引起的 2019 年冠状病毒病（COVID-19），这是一种最近在全球传播的病毒病原体。在 SARS-CoV2 感染中，PRL 的产生增加。虽然 PRL 可以触发促炎细胞因子的产生，但它也具有几种抗炎作用，可以减少过度炎症。PRL 对 COVID-19 严重程度的贡献的确切机制尚不清楚。本综述的目的是讨论 PRL 与 SARS-CoV2 感染的相互作用及其与 COVID-19 严重程度的可能关联。
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