催乳素-生乳激素在新冠病毒中的关键作用。
The crucial role of prolactin-lactogenic hormone in Covid-19.
机构信息
College of Medicine, Al-Mustansiriyah University, P.O. Box 14132, Baghdad, Iraq.
Chemistry & Biochemistry Discipline, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" From Timisoara, Calea Aradului 119, 300645, Timis, Romania.
出版信息
Mol Cell Biochem. 2022 May;477(5):1381-1392. doi: 10.1007/s11010-022-04381-9. Epub 2022 Feb 11.
Prolactin (PRL) is a peptide hormone secreted from anterior pituitary involved in milk production in the females and regulation of sex drive in both sexes. PRL has pro-inflammatory and anti-inflammatory functions. High PRL serum level or hyperprolactinemia is associated with different viral infections. In coronavirus disease 2019 (Covid-19), which caused by positive-sense single-strand RNA virus known as severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2), PRL serum level is increased. PRL in Covid-19 may exacerbate the underlying inflammatory status by induction release of pro-inflammatory cytokines. However, PRL through its anti-inflammatory effects may reduce the hyperinflammatory status in Covid-19. The underlying mechanism of increasing PRL in Covid-19 is poorly understood. Therefore, in this review we try to find the potential anti-inflammatory or pro-inflammatory role of PRL in Covid-19. As well, this review was aimed to discuss the underlying causes and mechanisms for Covid-19-induced hyperprolactinemia.
催乳素（PRL）是一种由垂体前叶分泌的肽类激素，参与女性的乳汁分泌和两性的性欲调节。PRL 具有促炎和抗炎功能。高催乳素血清水平或高催乳素血症与不同的病毒感染有关。在由正链单链 RNA 病毒引起的 2019 年冠状病毒病（Covid-19）中，催乳素血清水平升高。PRL 在 Covid-19 中可能通过诱导释放促炎细胞因子而加重潜在的炎症状态。然而，PRL 通过其抗炎作用可能减轻 Covid-19 中的过度炎症状态。催乳素在 Covid-19 中增加的潜在机制尚不清楚。因此，在本综述中，我们试图寻找 PRL 在 Covid-19 中的潜在抗炎或促炎作用。此外，本综述旨在讨论 Covid-19 引起的高催乳素血症的潜在原因和机制。
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