Department of Chemistry, Indian Institute of Technology Delhi, New Delhi 110016, India.
J Org Chem. 2023 Jul 7;88(13):8600-8608. doi: 10.1021/acs.joc.3c00511. Epub 2023 Jun 15.
An unprecedented C-1 selective mono-arylation/acylation of -protected carbazoles with aryl diazonium salts/glyoxylic acids has been developed in visible light by dual catalytic system comprising of Eosin Y and palladium acetate. The methodology has good functional group tolerance and high regioselectivity and furnishes the monosubstituted products in moderate to good yields at room temperature.
可见光条件下，通过双催化体系（曙红 Y 和醋酸钯），发展了首例 C-1 选择性单芳基化/酰化保护咔唑与重氮盐/乙醛酸。该方法具有良好的官能团耐受性和高区域选择性，在室温下以中等至良好的收率得到单取代产物。
