Visible-Light-Driven Regioselective Decarboxylative Acylation of -Methyl-3-phenylquinoxalin-2(1)-one by Dual Palladium-Photoredox Catalysis Through C-H Activation.

We report herein an efficient visible-light-promoted approach for the regioselective decarboxylative C-H acylation of -methyl-3-phenylquinoxalin-2(1)-ones using α-oxo-2-phenylacetic acids dual palladium-photoredox catalysis. The reactions were carried out at room temperature in the presence of 24 W blue LEDs. The established protocol tolerated a wide range of functional groups and enabled the synthesis of several acylated -methyl-3-phenylquinoxalin-2(1)-ones in good to excellent yields. The proposed mechanism for this transformation was supported by control experiments.