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广泛急性皮肤移植物抗宿主病：一例罕见的存活病例报告

Extensive acute cutaneous graft versus host disease: A rare case report of survival.

作者信息

Pudasaini Prajwal, Paudel Sushil, Sagar G C, Adhikari Sadiksha, Thapa Neeraj, Thapa Bibechan

机构信息

Department of Dermatology Civil Service Hospital Kathmandu Nepal.

Nepal Medical College Teaching Hospital Kathmandu Nepal.

出版信息

Clin Case Rep. 2023 Jun 13;11(6):e7545. doi: 10.1002/ccr3.7545. eCollection 2023 Jun.

DOI:10.1002/ccr3.7545
PMID:37323259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10264954/
Abstract

Graft versus host disease (GVHD) is an immunologically mediated condition seen in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Because of the rarity of the disease, nonspecific presentation, and lack of clinicopathological correlation, its diagnosis is often delayed and prompt treatment is deferred, with increased mortality.

摘要

移植物抗宿主病（GVHD）是同种异体造血干细胞移植（HSCT）受者中出现的一种免疫介导病症。由于该疾病罕见、表现不特异且缺乏临床病理相关性，其诊断常常延迟，及时治疗也被推迟，导致死亡率增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/6cebe6980abc/CCR3-11-e7545-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/4d3fbeb0c4b8/CCR3-11-e7545-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/c22022a9b1bd/CCR3-11-e7545-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/75f45f2b7d12/CCR3-11-e7545-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/6cebe6980abc/CCR3-11-e7545-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/4d3fbeb0c4b8/CCR3-11-e7545-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/c22022a9b1bd/CCR3-11-e7545-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/75f45f2b7d12/CCR3-11-e7545-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f99f/10264954/6cebe6980abc/CCR3-11-e7545-g001.jpg

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本文引用的文献

1
Disease progression, treatments, hospitalization, and clinical outcomes in acute GVHD: a multicenter chart review.急性移植物抗宿主病的疾病进展、治疗、住院和临床结局：一项多中心图表回顾。
Bone Marrow Transplant. 2022 Oct;57(10):1581-1585. doi: 10.1038/s41409-022-01764-w. Epub 2022 Jul 30.
2
Hematopoietic Stem Cell Transplantation in Nepal: International Partnership, Implementation Steps, and Clinical Outcomes.尼泊尔的造血干细胞移植：国际合作、实施步骤和临床结果。
Transplant Cell Ther. 2022 May;28(5):268-275. doi: 10.1016/j.jtct.2022.02.011. Epub 2022 Feb 16.
3
Treatment of Steroid-Refractory Acute Graft--Host Disease Using Commercial Mesenchymal Stem Cell Products.
使用商业间充质干细胞产品治疗激素难治性急性移植物抗宿主病。
Front Immunol. 2021 Aug 19;12:724380. doi: 10.3389/fimmu.2021.724380. eCollection 2021.
4
Risk Factors for Graft-versus-Host Disease in Haploidentical Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide.使用移植后环磷酰胺的单倍体造血细胞移植中移植物抗宿主病的危险因素
Biol Blood Marrow Transplant. 2020 Aug;26(8):1459-1468. doi: 10.1016/j.bbmt.2020.05.001. Epub 2020 May 17.
5
Cutaneous manifestations of acute and chronic graft-versus-host disease.急性和慢性移植物抗宿主病的皮肤表现。
G Ital Dermatol Venereol. 2020 Feb;155(1):76-87. doi: 10.23736/S0392-0488.19.06535-0.
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The EBMT activity survey report 2017: a focus on allogeneic HCT for nonmalignant indications and on the use of non-HCT cell therapies.2017年欧洲血液与骨髓移植协会（EBMT）活动调查报告：聚焦非恶性适应症的异基因造血细胞移植及非造血细胞疗法的应用
Bone Marrow Transplant. 2019 Oct;54(10):1575-1585. doi: 10.1038/s41409-019-0465-9. Epub 2019 Feb 6.
7
Cutaneous Graft-Versus-Host Disease: Diagnosis and Treatment.皮肤移植物抗宿主病：诊断与治疗。
Am J Clin Dermatol. 2018 Feb;19(1):33-50. doi: 10.1007/s40257-017-0306-9.
8
Cutaneous graft-versus-host disease after hematopoietic stem cell transplant - a review.造血干细胞移植后的皮肤移植物抗宿主病——综述
An Bras Dermatol. 2016 May-Jun;91(3):336-43. doi: 10.1590/abd1806-4841.20164180.
9
Histopathologic Features of Cutaneous Acute Graft-Versus-Host Disease in T-Cell-Depleted Peripheral Blood Stem Cell Transplant Recipients.T细胞去除的外周血干细胞移植受者皮肤急性移植物抗宿主病的组织病理学特征
Am J Dermatopathol. 2015 Jul;37(7):523-9. doi: 10.1097/DAD.0000000000000357.
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Biol Blood Marrow Transplant. 2014 Nov;20(11):1717-21. doi: 10.1016/j.bbmt.2014.06.031. Epub 2014 Jun 27.