Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.
Center for Precision Cancer Medicine, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell Rep Methods. 2023 May 22;3(5):100483. doi: 10.1016/j.crmeth.2023.100483.
In a recent issue of , Zecha et al. present decryptM, an approach aimed at defining the mechanisms of action of anti-cancer therapeutics through systems-level analysis of protein post-translational modifications (PTMs). By using a broad range of concentrations, decryptM generates drug response curves for each detected PTM, enabling identification of drug effects at different therapeutic doses.
在最近的一期《 》中，Zecha 等人提出了 decryptM 方法，该方法旨在通过对蛋白质翻译后修饰（PTMs）的系统水平分析来定义抗癌治疗药物的作用机制。通过使用广泛的浓度范围，decryptM 为每个检测到的 PTM 生成药物反应曲线，从而能够在不同的治疗剂量下识别药物的作用。
