Van der Meer K, Valkenburg P W, Bastiaans A C, Vleeming W, Ufkes J G, Ottenhof M
Eur J Pharmacol. 1986 May 27;124(3):299-308. doi: 10.1016/0014-2999(86)90231-1.
The effect of naloxone on a number of experimental shock models, using the anaesthetized rat, was studied with special emphasis on mean arterial blood pressure (MABP) and chance of survival. Only a slight increase in MABP was noted in haemorrhagic shock models whereas survival was not affected. Naloxone was without effect in endotoxin shock (i.p. administration of endotoxin). In endotoxin shock (i.v. administration) naloxone increased MABP especially at a high dose of endotoxin. Although survival time was prolonged, the chance of permanent survival was not improved. Naloxone had practically no effect in anaphylactic shock and intestinal ischaemia shock. It is concluded that if naloxone has any effect it is relatively slight. However, this does not exclude the possibility that naloxone might still be considered as an adjunct to other forms of shock treatment at least in certain types of shock.
使用麻醉大鼠，研究了纳洛酮对多种实验性休克模型的影响，特别关注平均动脉血压（MABP）和存活几率。在失血性休克模型中，仅观察到MABP略有升高，而存活情况未受影响。纳洛酮对内毒素休克（腹腔注射内毒素）无效。在内毒素休克（静脉注射）中，纳洛酮可升高MABP，尤其是在高剂量内毒素时。虽然存活时间延长，但永久存活的几率并未改善。纳洛酮在过敏性休克和肠缺血性休克中几乎没有作用。得出的结论是，如果纳洛酮有任何作用，其作用相对较小。然而，这并不排除纳洛酮至少在某些类型的休克中仍可被视为其他休克治疗形式的辅助药物的可能性。
