百日咳毒素可抑制吗啡对大鼠的镇痛作用。
Pertussis toxin inhibits the antinociceptive action of morphine in the rat.
作者信息
Parenti M, Tirone F, Giagnoni G, Pecora N, Parolaro D
出版信息
Eur J Pharmacol. 1986 May 27;124(3):357-9. doi: 10.1016/0014-2999(86)90240-2.
The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 micrograms) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 micrograms) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.
研究了脑室内注射（i.c.v.，0.5微克）百日咳毒素（PTX）对脑室内注射吗啡（5微克）诱导的大鼠镇痛作用的影响。毒素给药后24小时，吗啡镇痛作用未受影响，但6天后有显著下降。因此，一种对PTX敏感的底物，可能是一种鸟嘌呤核苷酸调节蛋白，可能参与了阿片受体与负责吗啡抗伤害感受作用表达的细胞效应器的偶联。
Zotero 插件