Wallaert B, Ramon P, Fournier E C, Hatron P Y, Muir J F, Tonnel A B, Voisin C
Eur J Respir Dis. 1986 Apr;68(4):256-62.
Intravenous methylprednisolone in "pulse" dose (30 mg/kg, once a week for 6 weeks) with or without oral maintenance corticosteroid therapy was administered to 12 patients with chronic sarcoidosis. Disease activity was evaluated by broncho-alveolar lavage, serum angiotensin converting enzyme assay and 67Ga scanning. Efficacy was assessed by clinical, radiological, and functional data. Pulse methylprednisolone produced immediate improvement in all patients but eight of the 12 patients relapsed 1 year later; one patient without maintenance corticosteroids and three patients with maintenance oral corticosteroids showed persistent improvement. However, there was no significant difference in criteria of disease activity of each patient before pulse therapy and 1 year later (p greater than 0.5). In conclusion, high dose therapy has immediate but transient effects whether or not it is supplemented by conventional corticosteroid therapy at the lower maintenance dosage.
对12例慢性结节病患者给予静脉注射“冲击”剂量的甲基强的松龙（30mg/kg，每周1次，共6周），部分患者联合或不联合口服维持性皮质类固醇治疗。通过支气管肺泡灌洗、血清血管紧张素转换酶测定和镓67扫描评估疾病活动度。通过临床、影像学和功能数据评估疗效。冲击剂量的甲基强的松龙使所有患者的病情立即得到改善，但12例患者中有8例在1年后复发；1例未接受维持性皮质类固醇治疗的患者和3例接受口服维持性皮质类固醇治疗的患者病情持续改善。然而，每位患者在冲击治疗前和1年后的疾病活动度标准无显著差异（p>0.5）。总之，无论是否补充较低维持剂量的传统皮质类固醇治疗，高剂量治疗均有即刻但短暂的效果。
