Ozerova L V, Stepanian I E, Romanov V V, Kireeva T A
Probl Tuberk. 1989(3):37-41.
One hundred and seventeen patients with active sarcoidosis of the respiratory organs were treated according to 4 therapy regimens based on the use of corticosteroid drugs. Intermittent use of the corticosteroids was shown to be the most efficient (in 98.5 per cent). It allowed to lower the course dose by 25-30 per cent and to reduce the frequency of complications to 1.5 per cent. Inspite of high efficacy of kenalog 40, its use was limited because of adverse reactions in 19.2 per cent of the patients. It was difficult to eliminate the adverse reactions because of the drug prolonged action. The use of presocyl provided improvement in 62 per cent of the patients having contraindications for corticosteroid therapy. Patients with marked pneumosclerotic lesions should be treated with simultaneous use of corticosteroids and azathioprine.
117例活动性呼吸器官结节病患者根据4种基于使用皮质类固醇药物的治疗方案进行治疗。结果显示，间歇使用皮质类固醇最为有效（有效率为98.5%）。这使得疗程剂量降低了25% - 30%，并发症发生率降至1.5%。尽管曲安奈德40疗效显著，但由于19.2%的患者出现不良反应，其使用受到限制。由于药物作用时间长，不良反应难以消除。对于有皮质类固醇治疗禁忌证的患者，使用环磷酰胺可使62%的患者病情改善。有明显肺硬化病变的患者应同时使用皮质类固醇和硫唑嘌呤进行治疗。
