Basran G S, Byrne A J, Hardy J G, Richardson M A
Eur J Respir Dis. 1986 May;68(5):336-41.
Plasma protein accumulation (PPA) was monitored in the lungs of patients with the adult respiratory distress syndrome (ARDS). Transferrin radiolabelled in vivo with indium-113m was used as the plasma protein marker. Ten patients with clinically defined ARDS, exhibiting increased PPA indices (greater than 1.0 X 10(-3) min-1), were given intravenous infusion of methylprednisolone (MP; 30 mg kg-1 over 10 min). The four patients in whom the PPA indices were reduced to below 0.5 X 10(-3) min-1 within 1 h of completion of MP infusion all survived. In the remaining six patients PPA indices remained above 0.5 X 10(-3) min-1 and five of them died. The PPA indices prior to administration of MP were not significantly different in the survivors (n = 5) and non-survivors (n = 5); however, after MP they were significantly lower in the survivors compared with the non-survivors (P less than 0.02). Thus the response to an infusion of MP, monitored as PPA, may provide a predictor of survival in ARDS.
在成人呼吸窘迫综合征（ARDS）患者的肺部监测血浆蛋白蓄积（PPA）情况。以体内用铟-113m标记的转铁蛋白作为血浆蛋白标志物。10例临床诊断为ARDS且PPA指数升高（大于1.0×10⁻³ min⁻¹）的患者静脉输注甲泼尼龙（MP；10分钟内30 mg/kg）。在MP输注完成后1小时内PPA指数降至0.5×10⁻³ min⁻¹以下的4例患者全部存活。其余6例患者PPA指数仍高于0.5×10⁻³ min⁻¹，其中5例死亡。MP给药前，存活者（n = 5）和非存活者（n = 5）的PPA指数无显著差异；然而，MP给药后，存活者的PPA指数显著低于非存活者（P＜0.02）。因此，以PPA监测对MP输注的反应可能为ARDS患者的生存提供预测指标。
