Padegaonkar Amol, Sharma Sourabh, Deshpande Mandar
Department of Surgical Oncology, Apollo Hospital, Seepat Road, Bilaspur, C.G India.
Department of Surgical Oncology, Pacific Medical College, Udaipur, Rajasthan India.
Indian J Surg Oncol. 2023 Jun;14(2):487-491. doi: 10.1007/s13193-021-01451-0. Epub 2021 Sep 10.
Lymph node status is an important prognostic factor in head and neck cancer. The purpose of this study is to investigate the prognostic value of lymph node density (LND) in node-positive oral cavity cancer patients who received surgery plus adjuvant radiotherapy. From January 2008 to December 2013, a total of 61 oral cavity squamous cell cancer patients who had positive lymph node and received surgery and adjuvant radiotherapy were analysed. LND was calculated for each patient. The endpoints were 5-year overall survival (OS) and 5-year disease-free survival. All patients were followed for a period of 5 years. Mean 5-year overall survival for cases with LND of ≤ 0.05 was 56.1 ± 11.6 months, whereas mean 5-year overall survival for cases with LND > 0.05 was 40.0 ± 21.6 months. Log rank is 0.04 95% CI = 53.4-65. Mean 5-year disease-free survival for cases with LND of ≤ 0.05 was 50.5 ± 15.8 months, whereas mean disease-free survival for cases with LND > 0.05 was 15.8 ± 22.9 months. Log rank 0.03 95% CI = 43.3-57.6. Nodal status, disease stage and lymph node density were found to be significant predictors of prognosis in univariate analysis. In multivariate analysis, only lymph node density is found to be the predictor of prognosis. LND is an important prognosis factor for 5-year OS and 5-year DFS in oral cavity squamous cell carcinoma.
淋巴结状态是头颈癌重要的预后因素。本研究旨在探讨淋巴结密度（LND）在接受手术加辅助放疗的淋巴结阳性口腔癌患者中的预后价值。2008年1月至2013年12月，共分析了61例有淋巴结阳性且接受手术和辅助放疗的口腔鳞状细胞癌患者。计算每位患者的LND。观察终点为5年总生存率（OS）和5年无病生存率。所有患者随访5年。LND≤0.05的病例5年总生存均值为56.1±11.6个月，而LND>0.05的病例5年总生存均值为40.0±21.6个月。对数秩检验P值为0.04，95%置信区间为53.4 - 65。LND≤0.05的病例5年无病生存均值为50.5±15.8个月，而LND>0.05的病例无病生存均值为15.8±22.9个月。对数秩检验P值为0.03，95%置信区间为43.3 - 57.6。单因素分析发现淋巴结状态、疾病分期和淋巴结密度是预后的显著预测因素。多因素分析中，仅发现淋巴结密度是预后的预测因素。LND是口腔鳞状细胞癌5年OS和5年DFS的重要预后因素。
