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Glycoconj J. 2021 Dec;38(6):735-746. doi: 10.1007/s10719-021-10020-0. Epub 2021 Sep 7.
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Invasive Haemophilus influenzae type a infection and polyarthritis in a 72-year-old Japanese man: A case report.72 岁日本男性侵袭性流感嗜血杆菌 a 感染合并多关节炎：病例报告。
J Infect Chemother. 2021 Jul;27(7):1084-1088. doi: 10.1016/j.jiac.2021.01.017. Epub 2021 Feb 15.
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Non-vaccine Haemophilus influenzae type a epiglottitis.非疫苗型甲型流感嗜血杆菌会厌炎
J Paediatr Child Health. 2021 Jul;57(7):1133-1135. doi: 10.1111/jpc.15146. Epub 2020 Aug 29.
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Clinical Characteristics and Adverse Clinical Outcomes of Invasive Haemophilus influenzae Serotype a Cases-United States, 2011-2015.2011-2015 年侵袭性 A 群流感嗜血杆菌病例的临床特征和不良临床结局-美国。
Clin Infect Dis. 2021 Dec 6;73(11):e3670-e3676. doi: 10.1093/cid/ciaa990.
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Epidemiology of Invasive Haemophilus influenzae Serotype a Disease-United States, 2008-2017.侵袭性甲型流感嗜血杆菌病的流行病学-美国，2008-2017 年。
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Isolated Oculomotor Nerve Palsy: A Unique Presentation of Haemophilus influenzae Type A Meningitis.孤立性动眼神经麻痹：甲型流感嗜血杆菌脑膜炎的一种独特表现。
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Infect Genet Evol. 2020 Jun;80:104205. doi: 10.1016/j.meegid.2020.104205. Epub 2020 Jan 22.
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Case report of congenital asplenia presenting with Haemophilus influenzae type a (Hia) sepsis: an emerging pediatric infection in Minnesota.先天性脾缺失症合并甲型流感嗜血杆菌（Hia）败血症病例报告：明尼苏达州一种新出现的儿科感染。
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大龄儿童A型血清型颅内感染报告。

Report of serotype a intracranial infections in older children.

作者信息

Probst Varvara, Shahoud Fadi, Osborne Aaron Fletcher, Alvarez Ana, Maraqa Nizar, Mirza Ayesha

机构信息

Department of Pediatrics University of Florida College of Medicine-Jacksonville Jacksonville Florida USA.

Department of Pediatrics Division of Infectious Diseases and Immunology University of Florida College of Medicine-Jacksonville Jacksonville Florida USA.

出版信息

Pediatr Investig. 2023 Mar 18;7(2):132-136. doi: 10.1002/ped4.12369. eCollection 2023 Jun.

DOI:10.1002/ped4.12369
PMID:37324595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10262899/
Abstract

INTRODUCTION

(Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.

CASE PRESENTATION

We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.

CONCLUSION

Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.

摘要

引言

流感嗜血杆菌（Hi）可分为可分型（a - f）和不可分型组。历史上，b型流感嗜血杆菌（Hib）一直是侵袭性感染的重要病原体之一。然而，在广泛接种Hib疫苗后，在过去几十年中发现了其他Hi血清型的出现，特别是a型流感嗜血杆菌（Hia），主要发生在5岁以下儿童中。

病例报告

我们报告了两例5岁以上患者在短时间内且在同一地理区域内检测到Hia的严重颅内感染病例。

结论

需要在全球范围内对所有年龄组进行与Hia相关疾病的流行病学研究和监测，以更好地了解Hia的临床和流行病学特征。这可以建立一个平台来开发针对Hia的候选疫苗，可能保护所有年龄段的儿童。