大龄儿童A型血清型颅内感染报告。
Report of serotype a intracranial infections in older children.
作者信息
Probst Varvara, Shahoud Fadi, Osborne Aaron Fletcher, Alvarez Ana, Maraqa Nizar, Mirza Ayesha
机构信息
Department of Pediatrics University of Florida College of Medicine-Jacksonville Jacksonville Florida USA.
Department of Pediatrics Division of Infectious Diseases and Immunology University of Florida College of Medicine-Jacksonville Jacksonville Florida USA.
出版信息
Pediatr Investig. 2023 Mar 18;7(2):132-136. doi: 10.1002/ped4.12369. eCollection 2023 Jun.
INTRODUCTION
(Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.
CASE PRESENTATION
We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.
CONCLUSION
Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.
引言
流感嗜血杆菌（Hi）可分为可分型（a - f）和不可分型组。历史上，b型流感嗜血杆菌（Hib）一直是侵袭性感染的重要病原体之一。然而，在广泛接种Hib疫苗后，在过去几十年中发现了其他Hi血清型的出现，特别是a型流感嗜血杆菌（Hia），主要发生在5岁以下儿童中。
病例报告
我们报告了两例5岁以上患者在短时间内且在同一地理区域内检测到Hia的严重颅内感染病例。
结论
需要在全球范围内对所有年龄组进行与Hia相关疾病的流行病学研究和监测，以更好地了解Hia的临床和流行病学特征。这可以建立一个平台来开发针对Hia的候选疫苗，可能保护所有年龄段的儿童。
Zotero 插件