Yoshino Hiroshi, Matsumoto Tomoko, Yoshino Gen
Fujita Health University School of Medicine, Toyoake, Japan.
Toyo-do clinic, Tokyo, Japan.
Gerontol Geriatr Med. 2023 Jun 9;9:23337214231179847. doi: 10.1177/23337214231179847. eCollection 2023 Jan-Dec.
Aging is known as one of the important risk factors for coronary artery disease (CAD). We explore whether an association of metabolic syndrome (Met-) increases subclinical atherosclerosis among elderly diabetic subjects estimating the plaque score () of the carotid artery. A total of 187 subjects were enrolled. Middle-aged and older groups were divided into two groups. -test and Chi-square test were also employed. Simple regression analysis for the was performed with respective risk factors as independent variables. After selection of independent variables, multiple regression analysis was performed to estimated the association of and dependent variable of the study. There were significant differences in body mass index (BMI) ( < .001), HbA1c ( < .01), TG ( < .05), and PS ( < .001) . Multiple regression analysis in middle-aged subjects showed that the determinant of were age ( < .001), BMI ( = .006), Met- ( = .004), and hs-CRP ( = .019). Multiple regression analysis in older subjects showed that neither age nor Met- was included as significant determinant of . An association of Met- is an important factor for progression of subclinical atherosclerosis, but it cannot be a significant determinant of if the subjects are limited within older group.
衰老被认为是冠状动脉疾病（CAD）的重要风险因素之一。我们通过评估老年糖尿病患者颈动脉斑块评分（）来探究代谢综合征（Met-）与亚临床动脉粥样硬化之间是否存在关联。共纳入187名受试者，分为中年组和老年组，同时采用t检验和卡方检验。以各风险因素为自变量对进行简单回归分析，在选择自变量后，进行多元回归分析以评估与研究的因变量之间的关联。体重指数（BMI）（ < .001）、糖化血红蛋白（HbA1c）（ < .01）、甘油三酯（TG）（ < .05）和斑块评分（PS）（ < .001）存在显著差异。中年受试者的多元回归分析表明，的决定因素为年龄（ < .001）、BMI（ = .006）、Met-（ = .004）和超敏C反应蛋白（hs-CRP）（ = .019）。老年受试者的多元回归分析表明，年龄和Met-均未被列为的显著决定因素。Met-的关联是亚临床动脉粥样硬化进展的重要因素，但如果受试者仅限于老年组，则它不是的显著决定因素。
