Usha S M R, Bindu C M, Chandrika N
Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, India.
Department of Biochemistry, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, Karnataka, India.
J Midlife Health. 2022 Oct-Dec;13(4):300-303. doi: 10.4103/jmh.jmh_67_22. Epub 2023 Apr 28.
Perimenopause phase of a woman's life is featured by decline in the ovarian activity, predisposing her to several health consequences. The signs and symptoms of thyroid disorders simulate those of menopausal features which may go unnoticed and can cause untoward complications in these women.
The primary objective is to screen women of perimenopausal age for thyroid disorders. The secondary objective is to examine the variations in thyroid hormone levels in these women with advancing age.
One hundred and forty-eight apparently healthy women between the age group of 46 and 55 years were study subjects. They were divided into, Group I which constituted women between 46 and 50 years and Group II consisted of women between 51 and 55 years. Thyroid profile comprising serum thyroid-stimulating hormone (TSH), serum total triiodothyronine (T), and serum total thyroxine (T) were estimated for all the women recruited in the study.
Subclinical hypothyroidism (SCH) and overt hypothyroidism (OH) were detected in 22 and 8 women who constituted 14.9% and 5.4%, respectively, of the total women populace. In Group I, it was noted that 17.1% and 1.8% of women were suffering from SCH and OH, respectively. In Group II, while 8.1% of the women had SCH, 16.2% of women had progressed to OH. TSH levels were significantly higher ( = 0.002) in women of Group II than in Group I, suggesting increase in TSH levels with advancing age.
Screening of perimenopausal women for thyroid disorders will assure timely detection and proper management which will aid in reducing the morbidity and associated complications.
女性生命中的围绝经期阶段以卵巢活动衰退为特征，使她易出现多种健康问题。甲状腺疾病的体征和症状与更年期特征相似，可能未被注意到，并且会在这些女性中引发不良并发症。
主要目的是对围绝经期女性进行甲状腺疾病筛查。次要目的是检查这些女性甲状腺激素水平随年龄增长的变化。
148名年龄在46至55岁之间的明显健康女性为研究对象。她们被分为两组，第一组由46至50岁的女性组成，第二组由51至55岁的女性组成。对所有纳入研究的女性进行甲状腺功能检查，包括血清促甲状腺激素（TSH）、血清总三碘甲状腺原氨酸（T）和血清总甲状腺素（T）。
在22名和8名女性中分别检测到亚临床甲状腺功能减退（SCH）和显性甲状腺功能减退（OH），分别占女性总人口的14.9%和5.4%。在第一组中，注意到分别有17.1%和1.8%的女性患有SCH和OH。在第二组中，虽然8.1%的女性患有SCH，但16.2%的女性已发展为OH。第二组女性的TSH水平显著高于第一组（P = 0.002），表明TSH水平随年龄增长而升高。
对围绝经期女性进行甲状腺疾病筛查将确保及时发现并进行适当管理，这将有助于降低发病率和相关并发症。
