由ADP4产生的苯基戊基酮和间异丁基甲氧基苯甲酸酯是具有广谱活性的强效抗菌剂。
Phenyl Pentyl Ketone and m-isobutyl Methoxy Benzoate Produced by ADP4 are Potent Antimicrobial Agents Displaying Broad Spectrum Activities.
作者信息
Singh Radha, Ali Mohd, Dubey Ashok K
机构信息
Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi, 110078 India.
Faculty of Pharmacy, Hamdard University, New Delhi, 110062 India.
出版信息
Indian J Microbiol. 2023 Jun;63(2):181-189. doi: 10.1007/s12088-023-01068-7. Epub 2023 Mar 16.
UNLABELLED
Isolation and identification of two antimicrobial compounds, a phenyl pentyl ketone () and m-isobutyl methoxy benzoate (), from ADP4 have been reported. Structure of the compounds were elucidated from analyses of spectral data that included LCMS/MS, NMR, FTIR and UV spectroscopies. Both the compounds displayed significant inhibition of and non- species of (NAC) pathogens including , which is currently a pathogen of global concern. Also, the compounds showed potent antagonistic activity against , another significant human pathogen. No cytotoxicity against HePG2 cells was observed with either of the compounds. Both displayed favourable drug likeness properties as determined by ADME and toxicological studies. Also, this is the first report on production of these anti-microbial compounds by an actinobacterium.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s12088-023-01068-7.
未标注
已有报道从ADP4中分离并鉴定出两种抗菌化合物，一种苯基戊基酮（）和间异丁基甲氧基苯甲酸酯（）。通过对包括液相色谱-质谱联用/质谱（LCMS/MS）、核磁共振（NMR）、傅里叶变换红外光谱（FTIR）和紫外光谱（UV）在内的光谱数据进行分析，阐明了这些化合物的结构。这两种化合物对包括目前全球关注的病原体在内的非结核分枝杆菌（NAC）病原体的和非种均表现出显著抑制作用。此外，这些化合物对另一种重要的人类病原体也显示出强大的拮抗活性。两种化合物均未观察到对HePG2细胞的细胞毒性。通过药物代谢动力学（ADME）和毒理学研究确定，两者均具有良好的类药性质。此外，这是关于放线菌产生这些抗菌化合物的首次报道。
补充信息
在线版本包含可在10.1007/s12088-023-01068-7获取的补充材料。
Zotero 插件